Helena Sofia Domingues

Scientific Associate
System Biology

Sofia Domingues is a Scientific Associate in the Cell Mechanics Laboratory leaded by Inês Pinto. Sofia focuses her research in the field of myelination by combining super-resolution microscopy techniques and biosensing into computational models able to predict oligodendrocyte cell differentiation towards myelination. This knowledge can be used to explore drug discovery programs aimed at enhancing remyelination and/or modulation of myelin protection in clinical conditions of demyelination or myelin homeostasis deregulation such as multiple sclerosis, spinal cord injury, leukodystrophies, neuro-psychiatric disorders and age-related cognitive decline. Sofia holds a PhD in Biology from the Max-Planck Institute of Neurobiology (Germany) and the University of Coimbra (Portugal). Before joining INL, Sofia did a post-doc at IBMC/I3S-University of Porto (Portugal) from 2010-2016.

Selected Publications

  • Domingues HS, Cruz A, Chan JR, Relvas JB, Rubinstein B and Pinto IM
    Mechanical plasticity during oligodendrocyte differentiation and myelination
    Nature Communications, under revision