Miguel Xavier is a Research Fellow at the INL working in the Department of Life Sciences within the Food Processing research group. Miguel’s work focuses on the development of a new Gut-On-Chip platform to assess the bioavailability and safety of orally administered compounds.
Miguel obtained his PhD from the University of Southampton (UK) where he investigated label-free approaches based on microfluidics to sort skeletal stem cells (SSCs) from human bone marrow. He also worked in Southampton as a post-doctoral research fellow investigating i) the use of Nanoflares to isolate SSCs based on novel markers identified by single-cell RNA sequencing using DropSeq and ii) the optimisation of a novel 3D microfluidic Lung-On-Chip model.
Since 2016 Miguel was the first author of 5 publications in international peer-reviewed journals. Miguel has also secured funding to support his research and received scientific awards including the Gold Medal for Excellence in Engineering by a Young Researcher at the STEM for Britain competition held in the UK at the houses of parliament.
- Miguel Xavier, Stefan H. Holm, Jason P. Beech, Daniel Spencer, Jonas O. Tegenfeldt, Richard O.C. Oreffo and Hywel Morgan
Label-free enrichment of primary human skeletal progenitor cells using deterministic lateral displacement
Lab on a Chip 19 (3), 513-523
- Miguel Xavier, Sofia D Santos, Diana M Leite, Débora A Moreira, Rita Castro, Victoria Leiro, Joao Rodrigues, Ana P Pêgo, and Helena Tomas
PAMAM Dendrimers: Blood-Brain Barrier Transport and Neuronal Uptake after Focal Brain Ischemia
Journal of Controlled Release 291, 65-79
- Miguel Xavier, María C. de Andrés, Daniel Spencer, Richard O.C. Oreffo and Hywel Morgan
Size and dielectric properties of skeletal stem cells change critically after enrichment and expansion from human bone marrow; consequences for microfluidic cell sorting
J. R. Soc. Interface 2017 14 20170233; DOI: 10.1098/rsif.2017.0233
- Miguel Xavier, Richard O.C. Oreffo and Hywel Morgan
Skeletal stem cell isolation: A review on the state-of-the-art microfluidic label-free sorting techniques
Biotechnology Advances, Volume 34, Issue 5, September–October 2016, Pages 908-923
- Miguel Xavier, Philipp Rosendahl, Maik Herbig, Martin Kräter, Daniel Spencer, Martin Bornhäuser, Richard O.C. Oreffo, Hywel Morgan, Jochen Guck and Oliver Otto
Mechanical phenotyping of primary human skeletal stem cells in heterogeneous populations by real-time deformability cytometry
Integrative Biology, 2016, 8, 616-623