Therapeutic Tools and Methods
In the therapeutic tools and methods group we envisage new approaches towards innovative drug delivery solutions. These approaches can either rely on (i) bottom-up strategies, like the self-assembly of building blocks (e.g. lipids, polymers) into nanocarrier particles for the delivery of drugs and genes, or (ii) on top-down micro/nano-fabrication of medical devices for sustained drug release. A combined approach (iii) is also used, where microdevices are developed for directing self-assembly of lipid-based nanocarriers with enhanced functions, not achievable with conventional methods.
While for the time being most of the emphasis is put on the development of such enabling technologies for drug/gene delivery, the long term goal is to work together with clinicians and use these technologies in the development of treatments for ageing-related diseases.
1- Nanocarriers for drug and gene delivery
2- Development and Application of Microneedles to Induce Immunotolerance in the Context of Multiple Sclerosis
[Nanotrainforgrowth program – COFUND Marie Curie Action, European Commission’s 7th Framework Programme].
Recent advances in multiple emulsions and their application as templates (Journal Article)
Curr. Opin. Colloid Interface Sci, 25 (98-108), 2016.
Nano- and micro-based systems for immunotolerance induction in Multiple Sclerosis (Journal Article)
Human Vaccines and Immunotherapeutics , 12 , pp. 1886 -1890, 2016.