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More about Bruno Silva

Bruno Silva

Staff Researcher


Bruno Silva holds a Licentiate (2004) and PhD (2009) in Chemistry from the University of Porto, Portugal. In both degrees he worked in the topics of Physical Chemistry, Soft Matter and Colloidal Science, under the guidance of Prof. Eduardo Marques. He focused on the phase behavior and nanostructure of self-assembled surfactant systems, using small-angle neutron scattering (SANS) as the main characterization tool.
As a Marie Curie postdoctoral fellow, he worked with Prof. Cyrus Safinya at the University of California Santa Barbara, USA, and Prof. Ulf Olsson at Lund University, Sweden. There he worked on the structural control of cationic liposome-DNA nanoparticles (also known as CL-DNAs or lipoplexes) and on the development of microfluidic devices with in-situ small-angle x-ray scattering (SAXS) for studies of soft matter under flow and out-of-equilibrium conditions.
In September 2015, he joined INL as a staff researcher to develop novel microfluidic-based methods to tailor with high accuracy the structure-function of lipid-DNA nanoparticles, and improve their efficiency for gene delivery in therapeutic applications.

Selected publications:

Bruno F.B. Silva, Miguel Z. Rosales, Neeraja Venkateswaran, Bretton J. Fletcher, Lester G. Carter, Tsutomu Matsui, Thomas M. Weiss, Jun Han, Youli Li, Ulf Olsson and Cyrus R. Safinya, “Nematic director reorientation at solid and liquid interfaces under flow: SAXS studies in a microfluidic device”, Langmuir, 31, 2015, 4361-4371 link

Bruno F.B. Silva, Ramsey N. Majzoub, Chia-Ling Chan, Youli Li, Ulf Olsson and Cyrus R. Safinya, “PEGylated Cationic Liposome – DNA Complexation in Brine is Pathway-Dependent” Biochim. Biophys. Acta – Biomembranes. 1838, 2014, 398-412 link

Bruno F.B. Silva, Eduardo F. Marques, Ulf Olsson and Per Linse, “Size, shape, and charge of salt-free catanionic microemulsion droplets: a small-angle neutron scattering and modeling study” J. Phys. Chem. B 113, 2009, 10230-10239 link

Bruno F. B. Silva, Eduardo F. Marques and Ulf Olsson, “Unusual vesicle-micelle transitions in a salt-free catanionic surfactant: temperature and concentration effects” Langmuir 24, 2008, 10746-10754 link

Eduardo F. Marques and Bruno F. B. Silva “Surfactant Self-Assembly” in Encyclopedia of Colloid and Interface Science, Tadros, T. (ed). Springer, 2013. ISBN 978-3-642-20664-1 link