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Precision Medicine Engineering

RESEARCH

DEPARTMENTS
Nanoelectronics engineering
RESEARCH GROUPS
SystemsEngineerings
nanodevices
spintronics
BTN_PME

DESCRIPTION

In the early 90’s, as the first human genome project was initiated, an extensive effort has been placed on mapping the role of genes in the onset of disease. Genetic contribution to different diseases however, were found to be varies and often very little, with non-genetic factors (e.g., environmental hazards, diet, microbiome) having much greater attributable risks, and thereby producing ‘stochastically’ large phenotypic pool. The key goal to understanding human health and disease is to access the ‘genotype-phenotype’ correlogram, and the success of translating precision medicine (e.g., molecular medicine) into clinical settings.

Weng Kung is the Group Leader for Precision Medicine Engineering Group (PME) under the Department of Nanoelectronic Engineering, INL. The team group interest focuses on developing and translating technological innovations (e.g., nuclear magnetic resonance (NMR), electron spin resonance, spintronic, Raman spectroscopic) for the next generation of precision medicine/agriculture at molecular level, which enables in-situ, rapid, high-throughput, and multidimensional molecular phenotyping in functional manner. Some of his team successful projects validated in clinical setting include the rapid and label-free malaria screening, high-throughput molecular phenotyping of oxidative stress in diabetes mellitus, sub-stratification of endometriosis, and multidimensional spectroscopy for molecular phenotyping in hemoglobinopathies.

RESEARCH PROJECTS

With advances in microelectronics technology, magnetic resonance (MR) community sees the emergence of portable and compact MR spectrometer (i.e., pulse programmer, trans-receiver, and digital signal processing) on a highly integrated circuit platform (e.g., field programmable gate array, complementary-metal-oxide semiconductor) targeting on in-situ applications such as disease diagnosis/monitoring, precision agriculture, and geological studies at point-of-use setting. This project aiming at designing and developing the  first integrated, scalable single chip, low field NMR spectrometry.

Development of microscale, in-situ NMR system. (a) First generation benchtop sized NMR system, which utilises a low-cost 0.5 Tesla permanent magnet, and a microcoil radio-frequency probe. Proton nuclei spin relaxations of water molecules can be used as a highly sensitive and specific molecular probe in biological fluids (e.g., red blood cells, tissues). (b) Less than 1µL of analyte is needed, and analysis typically completes in less than 5 minutes. (c) The second generation handheld micro NMR system roughly the size of a tablet. The system is controlled by using a field programmable array, powered by a 1 Watt amplifier chipset and a low-noise pre-amplifier.

In collaboration: System Engineering Group and Nanodevices Group

This project focuses on introducing the next generation of molecular phenotyping by exploiting the (ultra)fast, multidimensional NMR spectroscopic (in time and frequency domain) to produce highly unique molecular fingerprinting of biological fluids and cells/tissues, using microscale compact NMR system (e.g., low-field benchtop, hand-held single chip). Interested in particularly for down-stream medical research in chronic disease diagnosis/monitoring (e.g., diabetes mellitus, endometriosis, oxidative stress, dementia), in which we run several clinical studies over in Europe, China, and Southeast Asia.

Weng-Kung

High resolution mapping magnetic resonance relaxogram of a single drop blood using 2D Correlational Spectroscopy. 

GROUP LEADER

Weng-Kung-INL

THE TEAM

News Update

15 Dec 2017: We are hiring ! Several positions based in INL, Braga and China are available.

Candidates are expected to have PhD. in electrical engineering, material science, biochemistry or related fields. Relevant experience in multidimensional NMR spectroscopy, metabolomics NMR, instrumentation development (e.g., radiofrequency probe, gradient field), clean room microfabrication, or/and disease model (e.g., endometriosis, diabetes mellitus, dementia and oxidative stress) is highly preferred. Interested candidates may send his or her CV and cover letter to Weng Kung.

1 Dec 2017: New Research Collaboration
is initiated between INL, JCBI of Henan University and Macquarie University, to work on developing non-invasive NMR based molecular fingerprinting for brain disease (e.g., Alzheimer, Dementia) diagnosis and monitoring.

20 Nov 2017: A new research group focusing on translating technological innovations to clinical research, known as “Precision Medicine Engineering”  is formed at INL.

DESCRIPTION

In the early 90’s, as the first human genome project was initiated, an extensive effort has been placed on mapping the role of genes in the onset of disease. Genetic contribution to different diseases however, were found to be varies and often very little, with non-genetic factors (e.g., environmental hazards, diet, microbiome) having much greater attributable risks, and thereby producing ‘stochastically’ large phenotypic pool. The key goal to understanding human health and disease is to access the ‘genotype-phenotype’ correlogram, and the success of translating precision medicine (e.g., molecular medicine) into clinical settings.

Weng Kung is the Group Leader for Precision Medicine Engineering Group (PME) under the Department of Nanoelectronic Engineering, INL. The team group interest focuses on developing and translating technological innovations (e.g., nuclear magnetic resonance (NMR), electron spin resonance, spintronic, Raman spectroscopic) for the next generation of precision medicine/agriculture at molecular level, which enables in-situ, rapid, high-throughput, and multidimensional molecular phenotyping in functional manner. Some of his team successful projects validated in clinical setting include the rapid and label-free malaria screening, high-throughput molecular phenotyping of oxidative stress in diabetes mellitus, sub-stratification of endometriosis, and multidimensional spectroscopy for molecular phenotyping in hemoglobinopathies.

RESEARCH PROJECTS

With advances in microelectronics technology, magnetic resonance (MR) community sees the emergence of portable and compact MR spectrometer (i.e., pulse programmer, trans-receiver, and digital signal processing) on a highly integrated circuit platform (e.g.,  field programmable gate array, complementary-metal-oxide semiconductor) targeting on in-situ applications such as disease diagnosis/monitoring, precision agriculture, and geological studies at point-of-use setting. This project aiming at designing and developing the first integrated scalable single chip, low field NMR spectrometry.

Weng-Kung-1

 

Development of microscale, in-situ NMR system. (a) First generation benchtop sized NMR system, which utilises a low-cost 0.5 Tesla permanent magnet, and a microcoil radio-frequency probe. Proton nuclei spin relaxations of water molecules can be used as a highly sensitive and specific molecular probe in biological fluids (e.g., red blood cells, tissues).  (b) Less than 1µL of analyte is needed, and analysis typically completes in less than 5 minutes.  (c) The second generation handheld micro NMR system roughly the size of a tablet. The system is controlled by using a field programmable array, powered by a 1 Watt amplifier chipset and a low-noise pre-amplifier.

This project focuses on introducing the next generation of molecular phenotyping by exploiting the (ultra)fast, multidimensional NMR spectroscopic (in time and frequency domain) to produce highly unique molecular fingerprinting of biological fluids and cells/tissues, using microscale compact NMR system (e.g., low-field benchtop, hand-held single chip). Interested in particularly for down-stream medical research in chronic disease diagnosis/monitoring (e.g., diabetes mellitus, endometriosis, oxidative stress, dementia), in which we run several clinical studies over in Europe, China, and Southeast Asia.

Weng-Kung

High resolution mapping magnetic resonance relaxogram of (single drop) blood using 2D Correlational Spectroscopy.

Several Postdoctoral Research positions are available for these projects. Candidate is expected to have PhD. in electrical engineering, material science, biochemistry or related fields. Relevant experience in multidimensional NMR spectroscopy, metabolomics NMR, instrumentation development (e.g., rf probe, gradient field), clean room microfabrication and diseases model (e.g., cancer research, diabetes mellitus, dementia and oxidative stress) is highly preferred. Interested candidates may send his or her CV and cover letter to Weng Kung.

GROUP LEADER

Weng-Kung-INL

THE TEAM

News Update

15 Dec 2017: We are hiring ! Several positions based in INL, Braga and China are available.

Candidates are expected to have PhD. in electrical engineering, material science, biochemistry or related fields. Relevant experience in multidimensional NMR spectroscopy, metabolomics NMR, instrumentation development (e.g., radiofrequency probe, gradient field), clean room microfabrication, or/and disease model (e.g., endometriosis, diabetes mellitus, dementia and oxidative stress) is highly preferred. Interested candidates may send his or her CV and cover letter to Weng Kung.

1 Dec 2017: New Research Collaboration
is initiated between INL, JCBI of Henan University and Macquarie University, to work on developing non-invasive NMR based molecular fingerprinting for brain disease (e.g., Alzheimer, Dementia) diagnosis and monitoring.

20 Nov 2017: A new research group focusing on translating technological innovations to clinical research, known as “Precision Medicine Engineering”  is formed at INL.

RESEARCH

Nanoelectronics engineering
DEPARTMENTS
RESEARCH GROUPS
SystemsEngineerings
nanodevices
spintronics
BTN_PME