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Precision Medicine Engineering

RESEARCH

DEPARTMENTS
Nanoelectronics engineering
RESEARCH GROUPS
SystemsEngineerings
nanodevices
spintronics
BTN_PME

DESCRIPTION

In the early 90’s, as the first human genome project was initiated, an extensive effort has been placed on mapping the role of genes in the onset of disease. Genetic contribution to different diseases however, were found to be varies and often very little, with non-genetic factors (e.g., environmental hazards, diet, microbiome) having much greater attributable risks, and thereby producing ‘stochastically’ large phenotypic pool. The key goal to understanding human health and disease is to access the ‘genotype-phenotype’ correlogram, and the success of translating technological innovations (e.g., molecular medicine, molecular imaging) into clinical settings.

Weng Kung is the Group Leader for Precision Medicine Engineering Group (PME) under the Department of Nanoelectronic Engineering, INL. The team group interest focuses on developing and translating technological innovations (e.g., nuclear magnetic resonance, electron spin resonance, Raman spectroscopic) for the next generation of molecular phenotyping. Some of his team successful projects include the rapid and label-free malaria screening, high-throughput molecular phenotyping of oxidative stress in diabetes mellitus, sub-stratification of endometriosis, and multidimensional spectroscopy for molecular phenotyping in hemoglobinopathies.

RESEARCH PROJECTS

With advances in microelectronics technology, magnetic resonance community sees the emergence of portable and compact spectrometer (i.e., pulse programmer, trans-receiver, and digital signal processing) on a highly integrated circuit platform (e.g., field programmable gate array, complementary-metal-oxide semiconductor) targeting on in-situ applications such as disease diagnosis/monitoring, precision agriculture, and geological studies at point-of-use setting. This project aiming at designing and developing the  first integrated, scalable single chip, low field NMR spectrometry.

Development of microscale, in-situ NMR system. (a) First generation benchtop sized NMR system, which utilises a low-cost 0.5 Tesla permanent magnet, and a microcoil radio-frequency probe. Proton nuclei spin relaxations of water molecules can be used as a highly sensitive and specific molecular probe in biological fluids (e.g., red blood cells, tissues). (b) Less than 1µL of analyte is needed, and analysis typically completes in less than 5 minutes. (c) The second generation handheld micro NMR system roughly the size of a tablet. The system is controlled by using a field programmable array, powered by a 1 Watt amplifier chipset and a low-noise pre-amplifier.

This project focuses on introducing the next generation of molecular phenotyping by exploiting the (ultra)fast, multidimensional NMR spectroscopic (in time and frequency domain) to produce highly unique ´molecular fingerprinting´ of biological fluids obtained non-invasive directly from clinical patients. Interested in particularly for down-stream medical research in chronic disease diagnosis/monitoring (e.g., diabetes mellitus, endometriosis, oxidative stress, dementia), in which we run several clinical studies over in Europe, China, and Southeast Asia.

Weng-Kung

High resolution mapping magnetic resonance relaxogram of a single drop blood using 2D Correlational Spectroscopy. 

IN THE NEWS

AWARD HIGHLIGHTS

2018 : China 1000 Youth Talent Award
The Youth Thousand Talents Program is a talent recruitment program established by the Government of China in 2008. The program, which was established in the wake of the 2008 Global Financial Crisis, exists to recruit highly skilled university professors and researchers to China. It has the same prestigious as European Research Council Fellowship, and Australian Research Council Fellowship.

2014 : 100 Leading Global Thinker: A World Disrupted – Category ‘HEALERS’

Researchers have long known that malaria parasites feeds on iron-laden haemoglobin. So for the past few years, the race has been on to design a magnetic device that, to put it simply, can detect the “iron laden poops” that malaria parasites left behind, as one reporter wrote in Cleveland’s Plain Dealer. Each with their own prototype device in hand, Weng Kung and John Lewandowski, who refined his technology from an original concept developed by Brian Grimberg, are now eyeing to finish the line. This technologies are currently under development, but could save thousands from one of the world’s biggest killer.

About the Publisher: Chevron Corporation´s Foreign Policy magazine recognizes the world’s pre-eminent thought leaders and public intellectuals in an annual issue, “100 Leading Global Thinkers”. The editors of Foreign Policy select the 100 global thinkers based on their standout contributions over the previous year and their ability to translate ideas into action that change and shape the world. The list has become one of Foreign Policy’s most-read features. Honourees include a range of leaders, advocates, innovators, artists, government officials, and visionaries from around the world, such as Jennifer Doudna (CRISPR), Elizabeth Holmes (Theranos), Mark Zuckerberg (Facebook), and Jack Ma (Alibaba.com).

2014             Altmetric Top 10 Articles Ranking in 2014 Category Nature Medicine
2014             Altmetric Top 1000 Articles Ranking in 2014, Category Open
2014             2nd Prize Oral Award SMART Annual Scientific Meeting
2013             2nd Prize Poster Award SMART Annual Scientific Meeting
2012             Bronze Medal in Singapore TechVentureLab Pitching Forum
2011             SMART-MIT Technology Ignition Award
2009             SMART Massachusetts Institute of Technology Postdoctoral Fellowship
2003             Japanese Science and Technology Ministry Scholar Award
1996             International Olympiad Physics Competition (Distinction)
1996             Australian National Chemistry Quiz (Distinction)

GROUP LEADER

Weng-Kung-INL

THE TEAM

News Update

May 2018: Open call for the prestigious Marie Curie Fellowship

6 Dec 2017: Open call for the prestigious Marie Curie Fellowship

The International Iberian Nanotechnology Laboratory, in Braga (Portugal) is launching the third call for the NanoTRAINforGrowth II – INL Post-Doctoral Fellowship Programme. This programme aims to provide an opportunity for talented and motivated researchers (from all over the world and all nationalities) to carry out groundbreaking research projects working at INL. The is a highly competitive fellowship which carry the title of Marie-Curie Fellow. There will be two calls per year (around Dec/Jan and March/April). Do not forget to nominate the “Department of Nanoelectronic Engineering, INL” as host Department. Feel free to forward your inquiry to Weng Kung.

 

1 Dec 2017: We are hiring ! Several positions based in INL, Braga and China are available.

Candidates are expected to have PhD. in electrical engineering, material science, biochemistry or related fields. Relevant experience in multidimensional NMR spectroscopy, metabolomics NMR, instrumentation development (e.g., radiofrequency probe, gradient field), clean room microfabrication, or/and disease model (e.g., endometriosis, diabetes mellitus, dementia and oxidative stress) is highly preferred. Interested candidates may send his or her CV and cover letter to Weng Kung.

1 Dec 2017: New Research Collaboration
is initiated between INL, JCBI of Henan University and Macquarie University, to work on developing non-invasive NMR based molecular fingerprinting for brain disease (e.g., Alzheimer, Dementia) diagnosis and monitoring.

20 Nov 2017: A new research group focusing on translating technological innovations to clinical research, known as “Precision Medicine Engineering”  is formed at INL.

DESCRIPTION

In the early 90’s, as the first human genome project was initiated, an extensive effort has been placed on mapping the role of genes in the onset of disease. Genetic contribution to different diseases however, were found to be varies and often very little, with non-genetic factors (e.g., environmental hazards, diet, microbiome) having much greater attributable risks, and thereby producing ‘stochastically’ large phenotypic pool. The key goal to understanding human health and disease is to access the ‘genotype-phenotype’ correlogram, and the success of translating technological innovations (e.g., molecular medicine, molecular imaging) into clinical settings.

Weng Kung is the Group Leader for Precision Medicine Engineering Group (PME) under the Department of Nanoelectronic Engineering, INL. The team group interest focuses on developing and translating technological innovations (e.g., nuclear magnetic resonance, electron spin resonance, Raman spectroscopic) for the next generation of molecular phenotyping. Some of his team successful projects include the rapid and label-free malaria screening, high-throughput molecular phenotyping of oxidative stress in diabetes mellitus, sub-stratification of endometriosis, and multidimensional spectroscopy for molecular phenotyping in hemoglobinopathies.

RESEARCH PROJECTS

With advances in microelectronics technology, magnetic resonance (MR) community sees the emergence of portable and compact MR spectrometer (i.e., pulse programmer, trans-receiver, and digital signal processing) on a highly integrated circuit platform (e.g.,  field programmable gate array, complementary-metal-oxide semiconductor) targeting on in-situ applications such as disease diagnosis/monitoring, precision agriculture, and geological studies at point-of-use setting. This project aiming at designing and developing the first integrated scalable single chip, low field NMR spectrometry.

Weng-Kung-1

Development of microscale, in-situ NMR system. (a) First generation benchtop sized NMR system, which utilises a low-cost 0.5 Tesla permanent magnet, and a microcoil radio-frequency probe. Proton nuclei spin relaxations of water molecules can be used as a highly sensitive and specific molecular probe in biological fluids (e.g., red blood cells, tissues).  (b) Less than 1µL of analyte is needed, and analysis typically completes in less than 5 minutes.  (c) The second generation handheld micro NMR system roughly the size of a tablet. The system is controlled by using a field programmable array, powered by a 1 Watt amplifier chipset and a low-noise pre-amplifier.

This project focuses on introducing the next generation of molecular phenotyping by exploiting the (ultra)fast, multidimensional NMR spectroscopic (in time and frequency domain) to produce highly unique molecular fingerprinting of biological fluids and cells/tissues, using microscale compact NMR system (e.g., low-field benchtop, hand-held single chip). Interested in particularly for down-stream medical research in chronic disease diagnosis/monitoring (e.g., diabetes mellitus, endometriosis, oxidative stress, dementia), in which we run several clinical studies over in Europe, China, and Southeast Asia.

Weng-Kung

High resolution mapping magnetic resonance relaxogram of (single drop) blood using 2D Correlational Spectroscopy.

Several Postdoctoral Research positions are available for these projects. Candidate is expected to have PhD. in electrical engineering, material science, biochemistry or related fields. Relevant experience in multidimensional NMR spectroscopy, metabolomics NMR, instrumentation development (e.g., rf probe, gradient field), clean room microfabrication and diseases model (e.g., cancer research, diabetes mellitus, dementia and oxidative stress) is highly preferred. Interested candidates may send his or her CV and cover letter to Weng Kung.

IN THE NEWS

AWARD HIGHLIGHTS

2018 : China 1000 Youth Talent Award
The Youth Thousand Talents Program is a talent recruitment program established by the Government of China in 2008. The program, which was established in the wake of the 2008 Global Financial Crisis, exists to recruit highly skilled university professors and researchers to China. It has the same prestigious as European Research Council Fellowship, and Australian Research Council Fellowship.

2014 : 100 Leading Global Thinker: A World Disrupted – Category ‘HEALERS’

Researchers have long known that malaria parasites feeds on iron-laden haemoglobin. So for the past few years, the race has been on to design a magnetic device that, to put it simply, can detect the “iron laden poops” that malaria parasites left behind, as one reporter wrote in Cleveland’s Plain Dealer. Each with their own prototype device in hand, Weng Kung and John Lewandowski, who refined his technology from an original concept developed by Brian Grimberg, are now eyeing to finish the line. This technologies are currently under development, but could save thousands from one of the world’s biggest killer.

About the Publisher: Chevron Corporation´s Foreign Policy magazine recognizes the world’s pre-eminent thought leaders and public intellectuals in an annual issue, “100 Leading Global Thinkers”. The editors of Foreign Policy select the 100 global thinkers based on their standout contributions over the previous year and their ability to translate ideas into action that change and shape the world. The list has become one of Foreign Policy’s most-read features. Honourees include a range of leaders, advocates, innovators, artists, government officials, and visionaries from around the world, such as Jennifer Doudna (CRISPR), Elizabeth Holmes (Theranos), Mark Zuckerberg (Facebook), and Jack Ma (Alibaba.com).

2014             Altmetric Top 10 Articles Ranking in 2014 Category Nature Medicine
2014             Altmetric Top 1000 Articles Ranking in 2014, Category Open
2014             2nd Prize Oral Award SMART Annual Scientific Meeting
2013             2nd Prize Poster Award SMART Annual Scientific Meeting
2012             Bronze Medal in Singapore TechVentureLab Pitching Forum
2011             SMART-MIT Technology Ignition Award
2009             SMART Massachusetts Institute of Technology Postdoctoral Fellowship
2003             Japanese Science and Technology Ministry Scholar Award
1996             International Olympiad Physics Competition (Distinction)
1996             Australian National Chemistry Quiz (Distinction)

GROUP LEADER

Weng-Kung-INL

THE TEAM

News Update

May 2018: Open call for the prestigious Marie Curie Fellowship

6 Dec 2017: Open call for the prestigious Marie Curie Fellowship

The International Iberian Nanotechnology Laboratory, in Braga (Portugal) is launching the third call for the NanoTRAINforGrowth II – INL Post-Doctoral Fellowship Programme. This programme aims to provide an opportunity for talented and motivated researchers (from all over the world and all nationalities) to carry out groundbreaking research projects working at INL. The is a highly competitive fellowship which carry the title of Marie-Curie Fellow. There will be two calls per year (around Dec/Jan and March/April). Do not forget to nominate the “Department of Nanoelectronic Engineering, INL” as host Department. Feel free to forward your inquiry to Weng Kung.

 

1 Dec 2017: We are hiring ! Several positions based in INL, Braga and China are available.

Candidates are expected to have PhD. in electrical engineering, material science, biochemistry or related fields. Relevant experience in multidimensional NMR spectroscopy, metabolomics NMR, instrumentation development (e.g., radiofrequency probe, gradient field), clean room microfabrication, or/and disease model (e.g., endometriosis, diabetes mellitus, dementia and oxidative stress) is highly preferred. Interested candidates may send his or her CV and cover letter to Weng Kung.

1 Dec 2017: New Research Collaboration
is initiated between INL, JCBI of Henan University and Macquarie University, to work on developing non-invasive NMR based molecular fingerprinting for brain disease (e.g., Alzheimer, Dementia) diagnosis and monitoring.

20 Nov 2017: A new research group focusing on translating technological innovations to clinical research, known as “Precision Medicine Engineering”  is formed at INL.

RESEARCH

Nanoelectronics engineering
DEPARTMENTS
RESEARCH GROUPS
SystemsEngineerings
nanodevices
spintronics
BTN_PME