Nanomedicine Plasmonic Super-Resolution Microscopy
The distance-dependent plasmonic interaction effects can be used to perform super resolution fluorescence imaging, This fast super resolution technique allows for the study of live cells. Chizhik et al., (Nature Photonics, 2014) showed how a thin gold layer can be used as a nanoscale ruler for live cell super resolution imaging. We plan to build on these observations and extend this powerful technique for biomedical research.
Illustration of the live cell super resolution method as described in Nat. Phot. 8, 124–127 (2014). The distance-dependent fluorescence lifetimes of fluorophores in the near field of a plasmonic gold layer can be used to determine their axial location on the super resolution level with sensitivities down to 3-4 nm.