Environment monitoring, security and food quality control Targeted nanoparticles for delivery of marine phycotoxins with pharmacological potential as therapeutical agents
Presumably harboring the most bio-productive diversity, the SEA comprises a strategic and vast natural resource to discover novel ‘validated’ structures with novel modes of action, that cover biologically relevant chemical space. In fact, the marine pharmacological clinical pipeline has enjoyed a renaissance in the past few years. Nevertheless, to date, all marine natural-derived drugs, approved or under clinical trials, are from animal origin! Investigation on pharmacological potential, as therapeutical agents, of marine floras of high-density proliferation is underexplored, a paradox given their prolific scope of potent poisoning metabolites. The marine dinoflagellates blooms are among the most widespread distributed and harmful reported.
It is well known that nanostructural defects are the main cause of human diseases and disorders, therefore, diagnostic and therapeutic approaches involving nanoscale structures are surely conducive. Functional nanocarriers may be used as gainful all-in-one (bio)sensor for earlier detection of diverse biomarkers, leading to a more personalized treatment.
Centered on the above-mentioned premises, the proposed project paves the way to the validation of novel nanosized vehicles, for efficient delivery of highly bioactive marine phycotoxins as theranostic agents. In parallel, the optimal nano-features are also intent to be considered to assess new nanotechnological solutions for Aquatic Toxicology.