Nanomachines & Nanomanipulation Design, synthesis and characterization of biocompatible magnetic nanoparticles and derived materials for hyperthermia applications

Hyperthermia is a highly demanding application which requires the fulfillment of several chemical and physical requirements. The design of nanosized magnetic systems capable of generating heat under an alternate magnetic field has become one of the hottest topics in applied materials science research due to the potential application in specific treatments such as cancer therapy or temperature controlled drug delivery.

Biocompatible iron oxide-based nanoparticles (with adequate organic or inorganic coatings) are the most extensively studied material in hyperthermia due to their low toxicity and superparamagnetic behavior, with relatively high saturation magnetization and no remanence or coercive forces, making them suitable for in vivo applications. Several chemical and physical parameters have been found to play an important role in the main mechanisms involved in the hyperthermia response of these complex magnetic nano-systems, being directly related to the Brown and Neél relaxation times. Our approach in this project will include the design, synthesis and characterization of different biocompatible magnetic nanoparticles and derived materials, in order to explore, understand and optimize their hyperthermia response.

In this sense, with properly designed nano-heaters, the hyperthermia approach would constitute an original and novel solution not only in the biomedical field but also in other applied materials science researches.