INLResearchGroups-Alpuim_w

2D Materials and Devices

2D Materials and Devices (2DMD) Research Group

The 2D Materials and Devices research group (2DMD) focuses on CVD growth, transfer, and device fabrication, using 2D materials, clean-room technology, and Raman imaging for structural characterization. Particular attention is given to biosensing devices, where immuno-assays and DNA sensors based on graphene liquid-gate FETs were developed. The device’s specificity for particular biomarkers is achieved by functionalizing the graphene channel. Attomolar DNA detection based on electrochemical arrays of graphene microsensors is achieved. In the framework of the project NeuralGRAB funded by “La Caixa” Foundation, we are working with the University of Minho Medical School and the Madrid Astrobiology Center to achieve brain activity recording of a panel of neurotransmitters (Dopamine, GABA, Glutamate) with physiological spatiotemporal resolution using multiplexed graphene transistor platforms.

The 2DMD is active in flexible electronics, developing 2D materials-based inks, pastes, and slurries so that inkjet, screen-printing, or spray coating are available to deposit materials from the liquid phase to fabricate flexible devices at low cost. The research applications under development are electromagnetic shielding coatings, membranes for efficient liquid filtration, and energy harvesters based on transition-metal dichalcogenides (TMDs).

The 2DMD group research activity includes fabricating single-photon emitters from controlled defects in h-BN and graphene and TMD plasmonic devices that operate in the visible or sub-mm wavelength range. These activities collaborate with the INL Ultrafast Bio- and Nanophotonics and the NAPSD groups.

ON GOING RESEARCH PROJECTS

028114:  Total Budget: €239.924,23. Duration: 01 July 2018 – 30 June 2021.
This project’s main idea is to develop a new spectroscopic technique based on tunable plasmonics in graphene, by exploring the polarization dependent interaction of small biomolecules with terahertz (THz) radiation. Graphene is widely recognized as an ideal platform for strong light matter interactions due to its excellent plasmonic response in the mid-to-far infrared spectral range. In addition, the plasmonic response of graphene is highly tunable in real time using electrostatic gating. Fundamental structural features of peptides that are critically important for their functions can, in principle, be probed by polarization dependent spectroscopy in the THz range, as described in a recent simulation study, which also explicitly noted that THz chiroptical spectroscopy has not yet been demonstrated experimentally. The innovative aspect of this project is, therefore, to develop devices that realize this predicted technique for molecular analysis using spectroscopic plasmonics. Two different architectures will be developed for implementing strong light-matter interaction between graphene and biomolecules. In one approach, micrometer wide ribbons of graphene, patterned by optical lithography, act as the active plasmonic medium. The second approach consists of transferring a continuous graphene sheet onto a grating of high dielectric contrast provided by alternating lines of SiO2 and Al2O3 on a high resistivity silicon wafer. Both architectures are based on theoretical simulations developed and performed by the team members, who have recently published their studies in a book about graphene plasmonics. Specifically, the two device architectures are modeled using full electrodynamics calculations, which are faster and perform better than the conventional time domain integration of Maxwell’s equations. The high sensitivity of surface-based detection methods, including conventional noble metal plasmonics, makes them particularly advantageous for analyzing small quantities of biomolecules. Being a 2D material, graphene is a natural choice for implementing surface-based sensors.
Furthermore, the unique properties of the electromagnetic coupling of molecular excitations to surface plasmons in graphene open possibilities for extending the analytical capabilities of these sensors beyond the current state of the art for label-free measurements. Real-time tuning of plasmon resonances in graphene will enable spectroscopic, i.e., more specific, detection of biomolecules in presence of solvent and other background signals. This specificity will be enhanced by structural, e.g., chiral, signatures enabled by polarization dependent THz measurements. The specificity and information content of these measurements will be further enhanced by taking advantage of the high-intensity tunable broadband THz excitation produced by the two color air plasma method and of the time-resolved pump probe capabilities of the THz source and spectrometer to be developed in this project.
Main Goal: The idea of this project is to explore plasmons in graphene for a new spectroscopic technique. This technique covers the THz and the mid-IR. Graphene plasmons exist in these spectral ranges in which noble-metal plasmons are not available. The excitation of surface plasmons in graphene produces huge resonances in the extinction spectrum of the material. These resonances amplify tremendously the absorption signal due to molecules deposited on graphene and therefore can be used as a tool for the spectral identification of small quantities of analytes, down to a monolayer. The absorption of the analytes is due to their rotational and vibrational modes. The signal due to the absorption of the analytes is superimposed on the plasmonic resonance and appears as dips in the resonance signal. Depending on the rotational or vibrational excited energy levels, the dips are located at different positions, thus allowing an amplified spectroscopic signal.
Partners: CFUM (Coordinator), INN

POCI-01-0145-FEDER-031069:  Total Budget: €239.760,83. Duration: 15 June 2018 – 14 June 2021.
Portugal, and in particular the north region, is a leading producer of wine in the EU, with one of the highest numbers of DOP and IGPs in Europe, including world-known Port and Douro wines. Among common wine adulteration, the use of different grape varieties from the ones authorized by the PDO, or the use of more than one variety in wines labelled as monovarietal, are one of the issues of higher concern for producers and authorities.
DNA based analysis have become a very useful instrument on food and environmental analysis. DNA analysis is of high interest as well for varietal discrimination of grapes, wines, musts, and grape juice, due to the high specificity allowed by the use of DNA sequences, and the possibility of amplifying such DNA markers by PCR and other amplification strategies, and therefore obtaining higher sensitivity. Despite its advantages for grape variety identification, DNA analysis has not been extensively used by control laboratories, due to some drawbacks for their practical implementation. Several developments in the last years are being directed towards the improvement of DNA based analysis in order to simplify, miniaturize and reduce both the time and price of analysis with increased performance, to develop devices and methodology to be effectively used by control laboratories. Among such improvements, several sensors have been developed with promising characteristics, among them, field-effect transistors (FETs) allow to achieve high sensitivity, specificity and rapid measurement without the need of labelling, making them excellent candidates for wine/grape authenticity analysis. Likewise, there has been a strong interest in developing portable point-of-care devices that can be used in resource-limited settings, such as remote regions, farms or cultivars. Several approaches towards micro total analysis system (μTAS, or lab-on-a-chip) have been developed, which provides a significant improvement in performance. However, to our knowledge and despite of their clear advantages, no commercial μTAS are currently available and validated for DNA analysis in wine or food commodities.
Main Goal: The main objective of the project is the development, test and in-house validation of a miniaturized DNA sensing device for varietal discrimination of grapes, wines, musts, and grape juice in order to ensure the authenticity of wine from Port and Douro DOP. With this objective the participating teams will combine their expertise for the development of a miniaturized analytical device composed of 3 modules namely: a DNA extraction and purification module, an isothermal DNA amplification module, and a DNA Biosensors based on field-effect transistors (FETs) made using single layer graphene (SLG) for varietal discrimination. The integrated device will be in-house validated with different complex matrixes including grapes, wines, musts, and grape juice.
Partners: University of Minho

029417:  Total Budget: €239.886,50. Duration: 01 June 2018 – 31 May 2021.
The modifications of the fluorescence lifetime by the presence of fluorescence quenchers can be used to increase the axial resolution of fluorescence lifetime imaging microscopy (FLIM). The axial spatial range of the quencher material depends on its refractive index (RI), so materials with different RI can be explored in order to improve and modify the imaging axial range and axial resolution of FLIM. The main goal of the project is to optimize the FLIM technique for different resolutions and distance ranges to study different biological processes. Applications range from DNA detection to the time lapse super resolution imaging of live cells to track specific molecular biological processes in real time.
Main Goal: Optimization of a Fluorescence Lifetime Microscopy Imaging (FLIM) technique for axial super-resolution using various functional substrates and its application for biosensing and bioimaging.
Partners: University of Minho

FCT – SFRH/BD/128579/2017:  Duration: 01 September 2017 – 31 August 2021
“Immuno-field-effect transistor platforms based on 2D materials for early detection of biomarkers of ischemic stroke”, PhD project of Patrícia Daniela Cabral da Silva.
This thesis proposes to use clean-room micro and nanotechnology to fabricate label-free immuno-assays, based on graphene and other 2D material (hBN, MoS2) field-effect transistors, whose channel is functionalized for a set of biomarkers related with the hemorrhagic transformation in ischemic stroke. The project is based on the development, fabrication and testing of a multiplex microfluidic platform, which will be able to signal a panel of biomarkers at an early stage of the disease, thus contributing to spare the lives of many patients.

FCT – DRI/India/0664/2020:

Total Budget: €99 923,25. INL Budget: €99 923,25. Duration: 2022 – 2025
PL: Andrea Capasso
Energy harvesters (EHs) can provide the low amount of power required by an endless number of “small” low-power electronic devices, which are in enormous demand in diverse technology areas such as IoT. Photovoltaic (PV) cells and radio-frequency rectifying antennae (rectennae) are two kinds of versatile EHs, which could offer an ideal solution to source power in this context. Layered transition metal dichalcogenides (TMDCs) are a class of semiconductors with a plethora of excellent electronic and mechanical properties that can be combined and tuned to develop advanced lightweight and flexible devices in the field of energy harvesting. This proposal aims to demonstrate and extend the potential of ultra-thin TMDCs and conjugated polymers as building block for energy harvesters, tailoring their electro properties to achieve novel functions, and unprecedented device efficiencies. Moreover, this project will tackle a crucial and exploratory challenge by proposing a framework to engineer the on-demand electronic properties of the TMDCs according to specific device requirements. The TMDCs will be produced by innovative chemical vapor deposition techniques combined with suitable absorber materials such as conjugated polymers for energy harvesting applications. To this end, the proposal’s main objectives are O1: To innovate chemical deposition processes for the growth of TMDCs with fine control on crystallinity, thickness, and lateral size (up to cm2-wide samples). O2: To achieve efficient photo-generation in vertical TMDC P-N junctions made by plasma functionalization as building blocks for lightweight PV devices. O3: To create chemically functionalized lateral TMDC metal-semiconductor junctions that would enable fast rectification of RF signals for flexible rectennae. O4: To build energy harvesters for low-power electronics based on TMDCs combined with thin film absorbers. Based on these technologies, two proof of concept EH devices will be fabricated and tested. In the last stage of the project, a test on a dual device comprising both a PV device and a rectenna for complementary power generation will be conducted. The project will therefore lead to the following significant outcomes: 1. Engineering thickness, crystallinity, lateral size and doping profile of atomically thin transition metal dichalcogenides (TMDCs) could enable tuning of their electronic properties, improve device performance and/or induce altogether new working principles. 2. Coupling of TMDCs with conjugated polymers would lead to new physical mechanisms. This will transform our understanding towards universal energy-harvesting building blo and unleash new strategies that could lead to major advances in the field of high-performance optoelectronic devices. 3. Integrating PV cells and rectenna on a flexible substrate in a dual device prototype would significantly improve device performance by enabling complementary power generation. This approach can inspire future development of fast, low-cost, and flexible electronic systems paving their way for commercial applications. 4. Additionally, this work will also address key milestones for building a high-speed flexible RF radiation (wireless) and light-based energy hotspot systems.

“La Caixa” Health Research 2021 – HR21-00410:

Total Budget: €997,692.19. INL Budget: €417 298.76. Duration: 15 November 2021 – 14 November 2024
PL: Pedro Alpuim
Neurological disorders are a group of pathological conditions characterized by altered neuronal communication and impaired circuit and behavioral functions. Although multiple factors may cause different neurological disorders, altered neurotransmission is a shared mechanistic link. But how does the brain orchestrate simultaneous streams of several chemical neurotransmitters and electrical events to guide behavior and encode the right message? And how does this message become distorted in brain disorders? Unfortunately, we are still far from answers because we lack appropriate tools for probing in vivo neurotransmission and decoding chemical brain messages. Despite significant progress in monitoring brain electrical activity, sensing in vivo neurochemical dynamics in real-time remains a significant challenge. Current enzyme-based or voltammetry/amperometry approaches lack adequate selectivity, sensitivity, or spatiotemporal resolution for neural sensing, thus hampering progress towards understanding brain function. By combining RNA/DNA aptamer-based biosensors or “aptasensors” (CSIC, Spain), graphene field-effect transistors, and biosensors prototyping (INL, Spain/Portugal), with functional neurophysiological experiments (UM, Portugal), we will develop a novel bioelectronics neural interface to record not only in vivo brain electrical activity but also five different neurotransmitters simultaneously, with physiological spatiotemporal resolution. Novel technologies that can probe the brain’s language with more fidelity, such as the one we propose here, can have wide scientific community dissemination, be used as the backbone for next-generation brain-machine interfaces, and enable more advanced neuromorphic computers and machines. Ultimately this technology will help answer some fundamental questions regarding brain function in health and disease and allow inquiring about the underlying principles of the neuronal code supporting behavior.

PORTUGAL COMPETE 2020 – POCI – Projeto nº 45939:

Total Budget: €1 176 933,98. INL Budget: €507 999,00. Duration: 1 June 2020 – 1 June 2023
PL: Andrea Capasso
Electromagnetic interference (EMI) is an interesting phenomenon that affects all electronic devices working in an environment surrounded by external sources of radiated signals and electromagnetic radiation, such as antennas and other electronic devices. Current shielding materials used to protect electronic devices from EMI are based on heavy, brittle, and expensive metals, while the significant EMI applications have a huge demand for flexible, additive, light, and inexpensive materials. Graphene and related materials are considered the most promising and effective candidates for effective EMI shielding because of their excellent electrical properties, extremely high specific surface area, and unprecedented strength to weight ratio. The GEMIS project aims to develop versatile EMI shielding solutions based on graphene materials and technology and significantly impact several applications and sectors that require highly versatile shielding solutions that comply with various production processes. The project proposes the development of a universal formulation for a liquid dispersion of graphene materials with highly effective EMI shielding and the consequent production of two EMI shielding composites based on polymers and epoxies. Finally, a piece of custom-made equipment will be designed and fabricated to precisely apply the developed EMI shielding solutions on electric wires in the automotive industry. The GEMIS project will be promoted by a whole consortium consisting of a company with strong R&D skills – Graphenest – and two entities from the Portuguese Research and Innovation System, i.e., the International Laboratory of Iberian Nanotechnology and the University of Minho. In addition, the project will be supported by an international research entity, the University of Texas at Austin, and assisted by one national associated business partner – YAZAKI Saltano de Ovar Produtos Eléctricos Lda.

PROJECT TERMINATED

FCT – UTA-EXPL/NPN/0038/2019: 
Total Budget: €49 941,70. INL Budget: €45 441,61. Duration: 18 August 2020 – 15 November 2021
PL: Alexandre Chícharo
Infrared (IR) and particularly terahertz (THz) technologies have seen a significantly increase in research and development interest recently. THz radiation, also known as T-rays, fills the gap between microwave and infrared light and consists of electromagnetic (EM) waves within the frequency range from 0.3 to 30 THz. The primary applications of this technology include imaging in astronomy, spectroscopic techniques, detection of explosives, security screening applications for detecting hidden objects, larger broadband wireless data communication, dry food inspection, biosensor devices, new cancer treatments, etc. THz radiation is often referred to as the final unexplored area of the electromagnetic wave spectrum [1]. The main reason for this is the lack of compact and room-temperature THz sources powerful enough to achieve practical realization of the applications of these submillimeter waves. Therefore, with the demonstration of new sources, the trend of THz science and development of technology expects a huge growth, becoming one of the major fields of applied research. Currently, no satisfactory solutions for benchtop THz emission exist. The discovery of new THz sources and detectors that can operate at room conditions are miniaturized, easy-to-operate, capable of integration with other devices is desirable for many applications. Our objective is to fabricate and characterize next-generation THz emitters without requiring complex, bulky equipment or expensive vacuum systems. With the emergence of new advanced materials not available before, such as graphene and hexagonal Boron Nitrite, new functional transistors are being developed. These 2D materials present exceptional physical properties, such as high confined motilities or resistance, making them a natural choice for implementation in 2D semiconductors. Particularly, graphene is widely recognized as an ideal platform for strong light-matter interactions due to its excellent plasmonic response in the mid to THz spectral range.
Here, we propose a new on-chip THz emitter based on graphene field effect transistors using two geometries. We believe this technology would change the state-of-art of current THz emitters and broaden applications in many fields. New advanced computer simulation on quantum mechanics by our team at Instituto de Plasma e Fusão Nuclear (IPFN) proposes a pioneering scheme for generating coherent THz frequency combs in graphene FET (GFET), arising from the Dyakonov-Shur plasmonic instability. Results demonstrate the operation as a broadband THz light-emitting transistor excited via the injection of an electric current. This opens the potential for the development of an all-electric, low-power-consumption stimulated THz laser (THL), capable of operating at room temperature.

FCT – UTA-EXPL/NPN/0038/2019: 
Total Budget: €99 750,00. INL Budget: €59 750,00. Duration: 20 May 2019 – 31 October 2020
PL: Jérôme Borme
Malaria is a mosquito-borne infectious disease caused by parasitic protozoans belonging to the Plasmodium species (spp.). It is one of the deadliest diseases claiming half a million deaths annually, and its elimination is one of the aims declared on the UN Millennium Development Goals. The worldwide reduction of malaria prevalence raises the need for highly accurate diagnostic tools in order to treat the remaining cases. Moreover, due to the increase of people mobility worldwide, malaria diagnosis is also of extreme importance for developed countries as shown by recent increase of malaria-imported cases. Human malaria is caused by five Plasmodium species, each requiring specific treatment and intervention measures for disease control. The distribution of species prevalence within each affected region varies geographically and temporally. The clear identification of all species would allow to understand the intervention needs for malaria endemic locations. Currently, there is a lack of technologies for rapid diagnostics of malaria, addressing the diversity of malaria infections. Therefore, a device capable to detect and identify the all Plasmodium species is extremely useful for future field applications worldwide.
Here, we propose the development of the next generation of rapid diagnostic test for malaria, using a multiplex disposable graphene DNA based sensor device, to be the first distinguishing within all the five Plasmodium species. When compared to the state of the art, our project will: a) increase the accuracy of diagnosis of malaria through the discriminative nature of DNA together with the sensory properties of graphene; b) develop a sensing device with high sensitivity, crucial for the diagnosis of asymptomatic malaria; c) allow for the multiplex diagnosis of all malaria species that infect Humans in a single droplet of unprocessed biological samples (saliva, urine); d) take advantage of the high stability of graphene with regard to temperature and humidity which are crucial for applications in tropical settings; e) allow a less expensive, faster and user friendly diagnosis of malaria, when compared to standard DNA analysis procedures, without need for specialized personnel.
This proposal will contribute to the development of a novel and cost-effective point-of-care test, through the innovative application of novel graphene-based technologies addressed to ensure an early and rapid detection of malaria. The tool will be field-friendly allowing it to be implemented in resource-limited settings. Additionally, this detection strategy can be extended to other infectious agents increasing its potential. Overall, it is expected to bring considerable advances in the quality and reliability of patient care by enhanced monitoring and tracking of malaria transmission, through the early, discriminative, accurate and affordable diagnosis of malaria infections, which will pave the way for personalized medicine and, ultimately, malaria elimination.

POCI-01-0247-FEDER-033566:  Total Budget: €1.633.967,09. Duration: 01 August 2018 – 27 January 2020.
The market awareness to graphene and related materials has been growing steeply, as a result of promising results obtained in an experimental context. However, the application of these materials at an industrial scale has not yet been attained yet due to a number of constraints of the available production technologies, which can be generally resumed as an inability to simultaneously produce graphene in quantity, quality, and price, according to the needs of the industrial sector. Acknowledging this gap between the existing technologies and the industry needs, Graphenest has designed and developed an innovative technology, supported by a graphite exfoliation method in liquid phase using ultrasonic cavitation. Duly tested/validated at a laboratory scale, through the development of a prototype, Graphenest’s technology now needs further demonstration at a pre-industrial scale (and full industrial, at a later stage).
The GNESIS project emerges in this context, aiming at (i) assuring the scale-up of Graphenest’s technology into a pre-industrial scale and (ii) demonstrating the application of the graphene-based materials obtained from the referred technology in three different application areas, namely: anti-corrosion paints; polymers with electromagnetic shielding; and tactile screen electrodes. The GNESIS project will be promoted by a full consortium consisting of two companies with strong R&D skills – i.e., Graphenest (project leader) and Displax – as well as three entities from the Portuguese Research and Innovation System – i.e., the International Laboratory of Iberian Nanotechnology, University of Aveiro and University of Minho. In addition, the project will be attended by three national associated business partners – i.e., Bosch, CIN and Galp Energia – and an international one – the Chinese company Zhejiang Light-Tough Composite Materials.
Partners: GRAPHENEST S.A (Leader), DISPLAX S.A., Universidade de Aveiro, Universidade do Minho

PTDC/FIS-NAN/3668/2014: Total Budget: 146.508,00 €. Duration: 36 months.
This project aims at building a large area photodetector with 2D materials in a Van der Waals vertically stacked heterostructure. These devices are interesting because they are extremely thin (only a few atoms thick), flexible and with much better electronic properties than more conventional materials used, for example, in wearable devices. A photodetector of this type is composed by stacking a boron nitride buffer-layer, a graphene sheet, a multilayer transition metal dichalcogenide, a second graphene sheet, and a boron nitride encapsulating layer. Partners: LANASC group, UMinho

PTDC/CTM-ENE/2349/2014: Total Budget: 168.836,00 €. Duration: 24 months
This proposal aims to develop silicon based photocathodes coated with a chemically-inert thin protection layer and coupled with inexpensive, earth-abundant transition metal phosphide (TMP) nano-catalysts. The project focuses in developing photocathodes with a high open circuit potential that can potentially realize un-assisted solar water splitting, using tandem hydrogenated amorphous Si thin film solar cells coupled with TMP nano-catalysts as photocathodes.

PUBLICATIONS

  • 2021

    C. I. L. de Araujo, H. A. Teixeira, O. O. Toro, C. Liao, L. C. Benetti, J. Borme, D. Schafer, I. Brandt, R. Ferreira, P. Alpuim, Paulo P. Freitas, A. A. Pasa

    Room temperature two terminal tunnel magnetoresistance in a lateral graphene transistor Journal Article

    NANOSCALE, 2021.

    Abstract | Links | BibTeX

    Ruben F. Santos, Bruno M. C. Oliveira, Alexandre Chícharo, Pedro Alpuim, Paulo J. Ferreira, Sónia Simões, Filomena Viana, Manuel F. Vieira

    Seedless Cu Electroplating on Co-W Thin Films in Low pH Electrolyte: Early Stages of Formation Journal Article

    Nanomaterials , 11 (18), pp. 1914 , 2021.

    Abstract | Links | BibTeX

    Francesco Buonocore, Andrea Capasso, Massimo Celino, Nicola Lisi, Olivia Pulci

    Tuning the Electronic Properties of Graphane via Hydroxylation: An Ab Initio Study Journal Article

    JOURNAL OF PHYSICAL CHEMISTRY , 125 , pp. 16316-16323, 2021.

    Abstract | Links | BibTeX

    Bruna Silva, João Rodrigues, Balaji Sompalle, Chun-Da Liao, Nicoleta Nicoara, Jérôme Borme, Fátima Cerqueira, Marcel Claro, Sascha Sadewasser, Pedro Alpuim, Andrea Capasso

    Efficient ReSe2 Photodetectors with CVD Single-Crystal Graphene Contacts Journal Article

    Nanomaterials , 11 (7), pp. 1650 , 2021.

    Abstract | Links | BibTeX

    Balaji Sompalle, Chun-Da Liao, Bin Wei, Maria de Fátima Cerqueira, Nicoleta Nicoara, Zhongchang Wang, Sascha Sadewasser, Pedro Alpuim,

    Role of sublimation kinetics of ammonia borane in chemical vapor deposition of uniform, large-area hexagonal boron nitride Journal Article

    J. Vac. Sci. Technol. , A 39 (042202 ), 2021.

    Abstract | Links | BibTeX

    B. Jacob; F. Camarneiro; J. Borme; J. B. Nieder; B. Romeira

    Highly-efficient GaAs/AlGaAs Nanopillars and NanoLEDs via SiNx Surface Passivation Proceeding

    2021 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC) IEEE, Munich, Germany, 2021.

    Abstract | Links | BibTeX

    Sergey Tkachev, Miguel Monteiro, João Santos, Ernesto Placidi, Mohamed Ben Hassine, Pedro Marques, Paulo Ferreira, Pedro Alpuim, Andrea Capasso

    Environmentally Friendly Graphene Inks for Touch Screen Sensors Journal Article

    Adv. Funct. Mater., (2103287), pp. 15pp, 2021.

    Abstract | Links | BibTeX

    Andrea Capasso, João Rodrigues, Matteo Moschetta, Francesco Buonocore, Giuliana Faggio, Giacomo Messina, Min Jung Kim, Junyoung Kwon, Ernesto Placidi, Fabio Benfenati, Mattia Bramini, Gwan-Hyoung Lee, Nicola Lisi

    Interactions between Primary Neurons and Graphene Films with Different Structure and Electrical Conductivity Journal Article

    Advanced Functional Materials, 11 , 2021.

    Abstract | Links | BibTeX

    João Santos, Matteo Moschetta, João Rodrigues, Pedro Alpuim, Andrea Capasso

    Interactions Between 2D Materials and Living Matter: A Review on Graphene and Hexagonal Boron Nitride Coatings Journal Article

    Front. Bioeng. Biotechnol, 9:612669 , 2021.

    Abstract | Links | BibTeX

    Agnes Purwidyantri , Telma Domingues, Jérôme Borme, Joana Rafaela Guerreiro, Andrey Ipatov, Catarina M. Abreu, Marco Martins, Pedro Alpuim, Marta Prado

    Influence of the Electrolyte Salt Concentration on DNA Detection with Graphene Transistors Journal Article

    Biosensors , 11 (1), pp. 24, 2021.

    Abstract | Links | BibTeX

    Matteo Moschetta, Jong-Young Lee, João Rodrigues, Alice Podestà, Omar Varvicchio, Jangyup Son, Yangjin Lee ,Kwanpyo Kim, Gwan-Hyoung Lee, Fabio Benfenati, Mattia Bramini, Andrea Capasso

    Hydrogenated Graphene Improves Neuronal Network Maturation and Excitatory Transmission, Journal Article

    ADVANCED BIOLOGY, 2021.

    Abstract | Links | BibTeX

  • 2020

    G. Machado, Jr., M.F. Cerqueira, J. Borme, M. Martins, J. Gaspar, P. Alpuim

    Field-effect transistors made of graphene grown on recycled copper foils Journal Article

    Chem. Phys, 256 , pp. 123665, 2020.

    Abstract | Links | BibTeX

    A.Capasso, F.Muñoz-Rojas, B.Gupta, N.Motta, E.Placidi,

    Double grain boundary configurations on graphite surfaces Journal Article

    CARBON , 170 , pp. 630-635, 2020.

    Abstract | Links | BibTeX

    Patrícia D. Cabral, Telma Domingues, George Machado Jr., Alexandre Chícharo, Fátima Cerqueira, Elisabete Fernandes, Emília Athayde, Pedro Alpuim, Jérôme Borme

    Clean-Room Lithographical Processes for the Fabrication of Graphene Biosensors Journal Article

    Materials , 13 (24), pp. 5728, 2020.

    Abstract | Links | BibTeX

    Catarina M. Abreu, Victoria Thomas, Paul Knaggs, Adnan Bunkheila, Andrea Cruz, Sofia R. Teixeira, Pedro Alpuim, Lewis W. Francis, Amr Gebril, Ahmed Ibrahim, Lavinia Margarit, Deyarina Gonzalez, Paulo P. Freitas, R. Steven Conlan, Inês Mendes Pinto

    Non-invasive molecular assessment of human embryo development and implantation potential, Journal Article

    Biosensors & Bioelectronics , 157 (112144), 2020.

    Abstract | Links | BibTeX

    Hyokeun Lee, Min Jung Kim, Jong Hun Kim, Jong-Young Lee, Eunji Ji, Andrea Capasso, Heon-Jin Choi, Wooyoung Shim, Gwan-Hyoung Lee

    Highly flexible graphene nanoplatelet-polydimethylsiloxane strain sensors with proximity-sensing capability Journal Article

    MATERIALS RESEARCH EXPRESS , 7 , 2020.

    Abstract | Links | BibTeX

    V. Sousa, B.F. Gonçalves, Yitzchak S. Rosen, José Virtuoso, Pedro Anacleto, M. Fátima Cerqueira, Evgeny Modin, Pedro Alpuim, Oleg I. Lebedev, Shlomo Magdassi, Sascha Sadewasser, and Yury V. Kolen’ko

    Over 6% Efficient Cu(In,Ga)Se2 Solar Cell Screen-Printed from Oxides on Fluorine-Doped Tin Oxide Journal Article

    ACS Appl. Energy Mater, 3 (4), pp. 3120–3126, 2020.

    Abstract | Links | BibTeX

    Giuliana Faggio, Giacomo Messina, Caterina Lofaro, Nicola Lisi, Andrea Capasso

    Recent Advancements on the CVD of Graphene on Copper from Ethanol Vapor Journal Article

    C-JOURNAL OF CARBON RESEARCH, 6 , 2020.

    Abstract | Links | BibTeX

    Martha I. Ortiz-Torres, Miguel Fernández-Niño, Juan C. Cruz, Andrea Capasso, Fabio Matteocci, Edgar J. Patiño, Yenny Hernández, Andrés Fernando González Barrios

    Rational Design of Photo-Electrochemical Hybrid Devices Based on Graphene and Chlamydomonas reinhardtii Light-Harvesting Proteins Journal Article

    Scientific Reports, 6 , 2020.

    Abstract | Links | BibTeX

    Sojung Kang, Donghun Lee, Jonghun Kim, Andrea Capasso, Hee Seong Kang, Jin-Woo Park, Chul-Ho Lee, Gwan-Hyoung Lee

    2D semiconducting materials for electronic and optoelectronic applications: potential and challenge Journal Article

    2D MATERIALS , 7 (9), 2020.

    Abstract | Links | BibTeX

  • 2019

    Edite Figueiras Pedro Alpuim Jana Nieder B Ricardo M R Adão Rui Campos

    Graphene setting the stage: tracking DNA hybridization with nanoscale resolution Journal Article

    2D Materials, 6 , pp. 045056, 2019.

    Links | BibTeX

    Wan Bondarchuk Cerqueira Goncalves Bilotti Alpuim Rocha K O M F L M E P A M A.J. Paleo E.M.F. Vieira

    Negative thermoelectric power of melt mixed vapor grown carbon nanofiber polypropylene composites Journal Article

    Carbon, 150 , pp. 408-416, 2019.

    Links | BibTeX

    Rui Campos George Luiz Junior Fátima Cerqueira Cláudia Sousa Paulo Freitas Jérôme Borme Dmitri Petrovykh Pedro Alpuim M M P Y Elisabete Fernandes Patrícia D Cabral

    Functionalization of single-layer graphene for immunoassays Journal Article

    Apllied Surface Science, 480 , pp. 709-716, 2019.

    Links | BibTeX

    Joana Rafaela Guerreiro George Luiz Machado Jr Maria Fátima Cerqueira Dmitri Petrovykh Pedro Alpuim Rui Campos Jérôme Borme

    Attomolar label-free detection of DNA hybridization with electrolyte-gated graphene field-effect transistors Journal Article

    ACS Sensors, 4 (2), pp. 286-293, 2019.

    Links | BibTeX

  • 2018

    Viviana Sousa José Rodrigues Francis Leonard Deepak Yohei Kakefuda Naoyuki Kawamoto Tetsuya Baba Bryan Owens-Baird Pedro Alpuim Kirill Kovnir Takao Mori Yury Kolen’ko V Marek Piotrowski Miguel Franco

    Probing of Thermal Transport in 50 nm Thick PbTe Nanocrystal Films by Time-Domain Thermoreflectance Journal Article

    Journal of Physical Chemistry C, 122 (48), pp. 27127–27134, 2018.

    Abstract | Links | BibTeX

    Yu Xu Amorim Gaspar Qiao Ferreira Alpuim Liu K J I J L P P L S. Mouli Thalluri J. Borme

    Conformal and continuous deposition of bifunctional cobalt phosphide layers on p-silicon nanowire arrays for improved solar hydrogen evolution Journal Article

    Nano Research, 11 (9), pp. 4823–4835, 2018, ISSN: 1998-0124.

    Abstract | Links | BibTeX

    Sitaramanjaneya Mouli Thalluri; Jérôme Borme; Dehua Xiong; Junyuan Xu; Wei Li; Isilda Amorim; Pedro Alpuim; João Gaspar; Hélder Fonseca; Liang Qiao; Lifeng Liu

    Highly-ordered silicon nanowire arrays for photoelectrochemical hydrogen evolution: An investigation on the effect of wire diameter, length and inter-wire spacing Journal Article

    Sustainable Energy & Fuels, 2 (5), pp. 978-982, 2018.

    Abstract | Links | BibTeX

    Igor Bdkin Ankor González-Mayorga Gonzalo Irurueta Helena Nogueira María Serrano Pedro Alpuim Paula A.A.P.Marques I S C Gil Gonçalves Jérôme Borme

    Reductive nanometric patterning of graphene oxide paper using electron beam lithography Journal Article

    Carbon, 129 , pp. 63-75, 2018.

    Links | BibTeX

    Cerqueira Borme Alpuim M F J P R. Campos G. Machado Jr.

    Wafer scale fabrication of graphene microelectrode arrays for the detection of DNA hybridization Journal Article

    Microelectronic Engineering, 189 , pp. 85-90, 2018.

    Links | BibTeX

  • 2017

    Rebouta Cerqueira Alpuim Barradas Alves L M F P N P E A. Al-Rjoub P. Costa

    Characterization of magnetron sputtered sub-stoichiometric CrAlSiNx and CrAlSiOyNx coatings Journal Article

    Surface and Coatings Technology, 328 , pp. 134-141, 2017.

    Links | BibTeX

    Wei Li Junjie Li Xiuli Fu Cerqueira Pedro Alpuim M F Dehua Xiong Qingqing Zhang and Lifeng Liu

    Atomic-layer-deposited ultrafine MoS2 nanocrystals on cobalt foam for efficient and stable electrochemical oxygen evolution Journal Article

    Nanoscale, 9 , pp. 2711-2717, 2017.

    Links | BibTeX

  • 2016

    Nogueira SS Goncalves Cerqueira MF Alpuim Tovar Rodriguez-Abreu Brezesinski Gomes AC Lucio Oliveira P J C G M Oliveira ACN

    Role of counter-ion and helper lipid content in the design and properties of nanocarrier systems: a biophysical study in 2D and 3D lipid assemblies Journal Article

    RSC Advances, 53 , pp. 47730-47740, 2016.

    Links | BibTeX

    Machado Jr. Cerqueira Freitas Zucolotto Peres G F P P V N M R N. C. S. Vieira J. Borme and P Alpuim

    Graphene field-effect transistor array with integrated electrolytic gates scaled to 200 mm Journal Article

    Journal of Physics: Condensed Matter, 28 , pp. 085302, 2016.

    Links | BibTeX

    Iglesias Machado Jr. V G P. Alpuim M. F. Cerqueira and J Borme

    Laser patterning of amorphous silicon thin films deposited on flexible and rigid substrates Journal Article

    physica status solidi (a), 213 (7), pp. 1717-1727, 2016.

    Links | BibTeX

    Ana Mestre Pedro Inácio Bragança Jérôme Borme George Machado Jr. Fátima Cerqueira Pedro Alpuim J Sanaz Asgarifa Henrique L. Gomes

    Electrochemically Gated Graphene Field-Effect Transistor for Extracellular Cell Signal Recording Conference

    Technological Innovation for Cyber-Physical Systems, 470 , Springer, Cham, 2016, ISBN: 978-3-319-31165-4.

    Links | BibTeX

  • 2015

    Tondelier Vanel Geffroy Bonnassieux Alpuim Bourée D J C B Y P J E S. Majee M.F. Cerqueira

    Permeation barrier performance of Hot Wire-CVD grown silicon-nitride films treated by argon plasma Journal Article

    Thin Solid Films, 575 , pp. 72-75, 2015.

    Links | BibTeX

    Tondelier Geffroy Bonnassieux Alpuim Bourée D B Y P J E S. Majee M.F. Cerqueira

    Flexible organic–inorganic hybrid layer encapsulation for organic opto-electronic devices Journal Article

    Progress in Organic Coatings, 80 , pp. 27-32, 2015.

    Links | BibTeX

    Rocha Alpuim Machado Baumann Lanceros-Méndez J G P A V R R S H.F. Castro E. Sowade

    Degradation of all-inkjet-printed organic thin-film transistors with TIPS-pentacene under processes applied in textile manufacturing Journal Article

    Organic Electronics, 22 , pp. 12-19, 2015.

    Links | BibTeX

    Pedro Alpuim Xiao-Qing Bao M. Fatima Cerqueira and Lifeng Liu

    Silicon Nanowire Arrays Coupled with Cobalt Phosphide Spheres as a Low-Cost Photocathode for Efficient Solar Hydrogen Evolution Journal Article

    Chemical Communications, 51 (53), pp. 10742-10745, 2015.

    Links | BibTeX

    Pedro Alpuim Daniel Stroppa Noelia Guldris Helder Fonseca Margaret Costa Joao Gaspar Chuanhong Jin Lifeng Liu G Xiao-Qing Bao Dmitri Y. Petrovykh

    Amorphous oxygen-rich molybdenum oxysulfide decorated p-type silicon microwire arrays for efficient photoelectrochemical water reduction Journal Article

    Nano Energy, 16 , pp. 130-142, 2015.

    Links | BibTeX

    Cerqueira Tondelier Geffroy Bonnassieux Bourée M F D B Y J E P. Alpuim S.Majee

    Effect of argon ion energy on the performance of silicon nitride multilayer permeation barriers grown by hot-wire CVD on polymers Journal Article

    Thin Solid Films, 595 , pp. 258-265, 2015.

    Links | BibTeX

  • 2014

    Tondelier Geffroy Bonnassieux Alpuim Bourée D B Y P J E S. Majee M.F. Cerqueira

    Influence of low energy argon plasma treatment on the moisture barrier performance of hot wire-CVD grown SiNx multilayers Journal Article

    Japanese Journal of Applied Physics, 53 (5S1), pp. 05FM05, 2014.

    Links | BibTeX

    Rebouta Alpuim Garcia Júnior Tavares L P C B G L C J M.V. Castro M.F. Cerqueira

    Influence of hydrogen plasma thermal treatment on the properties of ZnO:Al thin films prepared by dc magnetron sputtering Journal Article

    Vacuum, 107 , pp. 145, 2014.

    Links | BibTeX

  • 2013

    Martins Ribeiro Alpuim Rocha Morales Atienza Lanceros-Mendez M S C P J G I C S V. Correia V. Sencadas

    Piezoresistive sensors for force mapping of hip-prostheses Journal Article

    Sensors and Actuators A, 195 , pp. 133, 2013.

    Links | BibTeX

    Tondelier Geffroy Bonnassieux Alpuim Bourée D B Y P J E S. Majee M.F. Cerqueira

    The effect of argon plasma treatment on the permeation barrier properties of silicon nitride layers Journal Article

    Surface & Coatings Technology, 235 , pp. 361, 2013.

    Links | BibTeX

GROUP LEADER

Pedro-Alpoim-1_w

THE TEAM

Andrea Capasso
Staff Researcher

Jérôme Borme
Staff Researcher

Siva Sankar
Research Fellow

João Fernandes
Research Fellow

João Rodrigues
Research Associate

Patrícia Cabral
PhD student

Ivo Colmiais
Ph.D. student

Vitor Silva
Ph.D. student

Juan Luís Garcia-Pomar
Research Associate

Ana Oliveira e Silva
Research Fellow

Diogo Baptista
M.Sc. Student

Telma Domingues
Ph.D. student

João Azevedo
M.Sc. Student

Maria de Fátima Cerqueira
Research Associate

Tiago Queirós
Ph.D. student

SCIENTIFIC VISITORS

Vishesh Saxena
INL Summer Student Internship (2018)

Saibal Mitra (Missouri State University, USA)
INL Scientific Associate (2018)

Daniela Ion-Ebrasu (National R&D Institute for Cryogenic and isotopic Technologies, Romania)
INL Scientific Associate (2018)

Jean-Eric Bourée (Ecole Polytechnique, France)
INL Scientific Associate (2018)

Reddithota Vidyasagar (UAveiro, Portugal)
INL Scientific Associate (2017)

Paulo Alexandre de Carvalho Gomes (IST, Portugal)
INL Master Student Associate (2017)

Renato Domingues
INL Summer Students Internship (2017)

Luis Quispe (University of Santa Catarina, Brazil)
INL- Cooperation Associate (2016-17)

Cédric Sebastien Martins Figueiredo (UMinho, Portugal)
INL Student Associate (2016)

Clarissa Towle (MIT, USA)
MIT-Portugal INL Summer Students Internship (2015)

Alexandre Faia de Carvalho (UAveiro, Portugal)
INL Master Student Associate (2015)

Helder Xavier Pereira Peixoto (UMinho, Portugal)
INL Student Associate (2013)

César Rui de Freitas Bernardo
INL Summer Students Internship (2012)

César Rui de Freitas Bernardo
INL Summer Students Internship (2012)

Subimal Majee (Ecole Polytechnique, France)
INL PhD Student Associate (2012)

2D Materials and Devices (2DMD) Research Group

The 2D Materials and Devices group (2DMD) research focus on CVD growth, transfer and device fabrication, using 2D materials, clean-room technology, and Raman imaging for structural characterization. Particular attention is given to biosensing devices, where immuno-assays and DNA sensors based on graphene liquid-gate FETs were developed. The devices specificity for particular biomarkers is achieved by functionalization of the graphene channel. DNA detection based on electrochemical arrays of graphene microsensors is achieved. The group is running collaborative projects on the fabrication of optoelectronic devices: a photodetector based on Van der Waals stacking of 2D materials (with LANASC and UMinho), and photocathodes that can potentially realize un-assisted solar water splitting by coupling tandem amorphous silicon solar cells with high efficiency hydrogen evolution electrodes (with NESC and IPV-5 Jülich). The 2DMD group research interests include the study of single photon emitters from controlled defects in h-BN (with Nanophotonics dept.) and the fabrication of graphene plasmonic devices that operate in the sub-mm wavelength range.

RESEARCH PROJECTS

028114:  Total Budget: €239.924,23. Duration: 01 July 2018 – 30 June 2021.
This project’s main idea is to develop a new spectroscopic technique based on tunable plasmonics in graphene, by exploring the polarization dependent interaction of small biomolecules with terahertz (THz) radiation. Graphene is widely recognized as an ideal platform for strong light matter interactions due to its excellent plasmonic response in the mid-to-far infrared spectral range. In addition, the plasmonic response of graphene is highly tunable in real time using electrostatic gating. Fundamental structural features of peptides that are critically important for their functions can, in principle, be probed by polarization dependent spectroscopy in the THz range, as described in a recent simulation study, which also explicitly noted that THz chiroptical spectroscopy has not yet been demonstrated experimentally. The innovative aspect of this project is, therefore, to develop devices that realize this predicted technique for molecular analysis using spectroscopic plasmonics. Two different architectures will be developed for implementing strong light-matter interaction between graphene and biomolecules. In one approach, micrometer wide ribbons of graphene, patterned by optical lithography, act as the active plasmonic medium. The second approach consists of transferring a continuous graphene sheet onto a grating of high dielectric contrast provided by alternating lines of SiO2 and Al2O3 on a high resistivity silicon wafer. Both architectures are based on theoretical simulations developed and performed by the team members, who have recently published their studies in a book about graphene plasmonics. Specifically, the two device architectures are modeled using full electrodynamics calculations, which are faster and perform better than the conventional time domain integration of Maxwell’s equations. The high sensitivity of surface-based detection methods, including conventional noble metal plasmonics, makes them particularly advantageous for analyzing small quantities of biomolecules. Being a 2D material, graphene is a natural choice for implementing surface-based sensors.
Furthermore, the unique properties of the electromagnetic coupling of molecular excitations to surface plasmons in graphene open possibilities for extending the analytical capabilities of these sensors beyond the current state of the art for label-free measurements. Real-time tuning of plasmon resonances in graphene will enable spectroscopic, i.e., more specific, detection of biomolecules in presence of solvent and other background signals. This specificity will be enhanced by structural, e.g., chiral, signatures enabled by polarization dependent THz measurements. The specificity and information content of these measurements will be further enhanced by taking advantage of the high-intensity tunable broadband THz excitation produced by the two color air plasma method and of the time-resolved pump probe capabilities of the THz source and spectrometer to be developed in this project.
Main Goal: The idea of this project is to explore plasmons in graphene for a new spectroscopic technique. This technique covers the THz and the mid-IR. Graphene plasmons exist in these spectral ranges in which noble-metal plasmons are not available. The excitation of surface plasmons in graphene produces huge resonances in the extinction spectrum of the material. These resonances amplify tremendously the absorption signal due to molecules deposited on graphene and therefore can be used as a tool for the spectral identification of small quantities of analytes, down to a monolayer. The absorption of the analytes is due to their rotational and vibrational modes. The signal due to the absorption of the analytes is superimposed on the plasmonic resonance and appears as dips in the resonance signal. Depending on the rotational or vibrational excited energy levels, the dips are located at different positions, thus allowing an amplified spectroscopic signal.
Partners: CFUM (Coordinator), INN

POCI-01-0145-FEDER-031069:  Total Budget: €239.760,83. Duration: 15 June 2018 – 14 June 2021.
Portugal, and in particular the north region, is a leading producer of wine in the EU, with one of the highest numbers of DOP and IGPs in Europe, including world-known Port and Douro wines. Among common wine adulteration, the use of different grape varieties from the ones authorized by the PDO, or the use of more than one variety in wines labelled as monovarietal, are one of the issues of higher concern for producers and authorities.
DNA based analysis have become a very useful instrument on food and environmental analysis. DNA analysis is of high interest as well for varietal discrimination of grapes, wines, musts, and grape juice, due to the high specificity allowed by the use of DNA sequences, and the possibility of amplifying such DNA markers by PCR and other amplification strategies, and therefore obtaining higher sensitivity. Despite its advantages for grape variety identification, DNA analysis has not been extensively used by control laboratories, due to some drawbacks for their practical implementation. Several developments in the last years are being directed towards the improvement of DNA based analysis in order to simplify, miniaturize and reduce both the time and price of analysis with increased performance, to develop devices and methodology to be effectively used by control laboratories. Among such improvements, several sensors have been developed with promising characteristics, among them, field-effect transistors (FETs) allow to achieve high sensitivity, specificity and rapid measurement without the need of labelling, making them excellent candidates for wine/grape authenticity analysis. Likewise, there has been a strong interest in developing portable point-of-care devices that can be used in resource-limited settings, such as remote regions, farms or cultivars. Several approaches towards micro total analysis system (μTAS, or lab-on-a-chip) have been developed, which provides a significant improvement in performance. However, to our knowledge and despite of their clear advantages, no commercial μTAS are currently available and validated for DNA analysis in wine or food commodities.
Main Goal: The main objective of the project is the development, test and in-house validation of a miniaturized DNA sensing device for varietal discrimination of grapes, wines, musts, and grape juice in order to ensure the authenticity of wine from Port and Douro DOP. With this objective the participating teams will combine their expertise for the development of a miniaturized analytical device composed of 3 modules namely: a DNA extraction and purification module, an isothermal DNA amplification module, and a DNA Biosensors based on field-effect transistors (FETs) made using single layer graphene (SLG) for varietal discrimination. The integrated device will be in-house validated with different complex matrixes including grapes, wines, musts, and grape juice.
Partners: University of Minho

029417:  Total Budget: €239.886,50. Duration: 01 June 2018 – 31 May 2021.
The modifications of the fluorescence lifetime by the presence of fluorescence quenchers can be used to increase the axial resolution of fluorescence lifetime imaging microscopy (FLIM). The axial spatial range of the quencher material depends on its refractive index (RI), so materials with different RI can be explored in order to improve and modify the imaging axial range and axial resolution of FLIM. The main goal of the project is to optimize the FLIM technique for different resolutions and distance ranges to study different biological processes. Applications range from DNA detection to the time lapse super resolution imaging of live cells to track specific molecular biological processes in real time.
Main Goal: Optimization of a Fluorescence Lifetime Microscopy Imaging (FLIM) technique for axial super-resolution using various functional substrates and its application for biosensing and bioimaging.
Partners: University of Minho

POCI-01-0247-FEDER-033566:  Total Budget: €1.633.967,09. Duration: 01 August 2018 – 27 January 2020.
The market awareness to graphene and related materials has been growing steeply, as a result of promising results obtained in an experimental context. However, the application of these materials at an industrial scale has not yet been attained yet due to a number of constraints of the available production technologies, which can be generally resumed as an inability to simultaneously produce graphene in quantity, quality, and price, according to the needs of the industrial sector. Acknowledging this gap between the existing technologies and the industry needs, Graphenest has designed and developed an innovative technology, supported by a graphite exfoliation method in liquid phase using ultrasonic cavitation. Duly tested/validated at a laboratory scale, through the development of a prototype, Graphenest’s technology now needs further demonstration at a pre-industrial scale (and full industrial, at a later stage).
The GNESIS project emerges in this context, aiming at (i) assuring the scale-up of Graphenest’s technology into a pre-industrial scale and (ii) demonstrating the application of the graphene-based materials obtained from the referred technology in three different application areas, namely: anti-corrosion paints; polymers with electromagnetic shielding; and tactile screen electrodes. The GNESIS project will be promoted by a full consortium consisting of two companies with strong R&D skills – i.e., Graphenest (project leader) and Displax – as well as three entities from the Portuguese Research and Innovation System – i.e., the International Laboratory of Iberian Nanotechnology, University of Aveiro and University of Minho. In addition, the project will be attended by three national associated business partners – i.e., Bosch, CIN and Galp Energia – and an international one – the Chinese company Zhejiang Light-Tough Composite Materials.
Partners: GRAPHENEST S.A (Leader), DISPLAX S.A., Universidade de Aveiro, Universidade do Minho

FCT – SFRH/BD/128579/2017:  Duration: 01 September 2017 – 31 August 2021
“Immuno-field-effect transistor platforms based on 2D materials for early detection of biomarkers of ischemic stroke”, PhD project of Patrícia Daniela Cabral da Silva.
This thesis proposes to use clean-room micro and nanotechnology to fabricate label-free immuno-assays, based on graphene and other 2D material (hBN, MoS2) field-effect transistors, whose channel is functionalized for a set of biomarkers related with the hemorrhagic transformation in ischemic stroke. The project is based on the development, fabrication and testing of a multiplex microfluidic platform, which will be able to signal a panel of biomarkers at an early stage of the disease, thus contributing to spare the lives of many patients.

NORTE-01-0145-FEDER-000023:  Total Budget: €3.284.706,21. Duration: 01 April 2016 – 31 March 2019 (36 months).
The main of objective of FROnTHERA is to boost the progress of Tissue Engineering and Regenerative Medicine fields with main focus on cancer, diabetes and neurodegenerative diseases. To accomplish this, the merge of 3D tissue engineered in vitro models of diseases, microfluidics, nanotechnologies, molecular biology and embedded biosensors will be pursued in order to obtain new tools and technologies to be used as alternative to animal experimentation, as well as, personalized therapies for Human health. Ultimately, the strengthening of these interdisciplinary domains will allow the improvement of theranostics of RIS3 diseases. This project is an initiative of three top leading research units, located in the PT 11 region, and gathers experts in tissue engineering in vitro models, neurosciences and emergent technologies based on responsive biosensors, whose main goal is to dvance in research for developing tools and technologies to be used as alternative to animal experimentation and in personalised therapies for human health.
Partners: 3B’s

NORTE-01-0145-FEDER-000019:  Total Budget: €2.547.789,00. Duration: 01 April 2016 – 31 March 2018 (24 months).
The major goals set for the integrated project cover an increase of our human resources in strategic areas by hiring 15 new researchers for the 2 research lines, a strengthening of our core activities in various project areas (sensing, system integration etc.) as well as the opening of new scientific topics (thermal energy harvesting, label free optical/graphene biosensors, etc.), and re-enforcing partnerships and collaborations with major national/regional industrial actors (electronics, health, food and environment, materials ).
Line 1-Nanotechnology based autonomous sensing systems – (energy harvesting and storage, sensors, new materials and concepts, systems integration towards IOT)
Line 2-Nanotechnology enabled solutions for water, food, and health challenges – (Water monitoring and treatment, food quality and safety, food processing and subproduct valorization, nano in diagnostics, nano in therapeutics)
The program will provide nanotechnology-based solutions for 2 areas: autonomous sensing systems (targeting Internet-of-Things integration) and monitoring and treatment platforms for applications related to water, food, and health. Each challenge is the focus of a research line, while the program integrates both lines at several levels via shared and reciprocal goals, new technology platforms and (nano)materials, and characterization methods.

PTDC/FIS-NAN/3668/2014: Total Budget: 146.508,00 €. Duration: 36 months.
This project aims at building a large area photodetector with 2D materials in a Van der Waals vertically stacked heterostructure. These devices are interesting because they are extremely thin (only a few atoms thick), flexible and with much better electronic properties than more conventional materials used, for example, in wearable devices. A photodetector of this type is composed by stacking a boron nitride buffer-layer, a graphene sheet, a multilayer transition metal dichalcogenide, a second graphene sheet, and a boron nitride encapsulating layer. Partners: LANASC group, UMinho

PTDC/CTM-ENE/2349/2014: Total Budget: 168.836,00 €. Duration: 24 months
This proposal aims to develop silicon based photocathodes coated with a chemically-inert thin protection layer and coupled with inexpensive, earth-abundant transition metal phosphide (TMP) nano-catalysts. The project focuses in developing photocathodes with a high open circuit potential that can potentially realize un-assisted solar water splitting, using tandem hydrogenated amorphous Si thin film solar cells coupled with TMP nano-catalysts as photocathodes.

PUBLICATIONS

  • 2019

    Edite Figueiras Pedro Alpuim Jana Nieder B Ricardo M R Adão Rui Campos

    Graphene setting the stage: tracking DNA hybridization with nanoscale resolution Journal Article

    2D Materials, 6 , pp. 045056, 2019.

    Links | BibTeX

    Wan Bondarchuk Cerqueira Goncalves Bilotti Alpuim Rocha K O M F L M E P A M A.J. Paleo E.M.F. Vieira

    Negative thermoelectric power of melt mixed vapor grown carbon nanofiber polypropylene composites Journal Article

    Carbon, 150 , pp. 408-416, 2019.

    Links | BibTeX

    Rui Campos George Luiz Junior Fátima Cerqueira Cláudia Sousa Paulo Freitas Jérôme Borme Dmitri Petrovykh Pedro Alpuim M M P Y Elisabete Fernandes Patrícia D Cabral

    Functionalization of single-layer graphene for immunoassays Journal Article

    Apllied Surface Science, 480 , pp. 709-716, 2019.

    Links | BibTeX

    Joana Rafaela Guerreiro George Luiz Machado Jr Maria Fátima Cerqueira Dmitri Petrovykh Pedro Alpuim Rui Campos Jérôme Borme

    Attomolar label-free detection of DNA hybridization with electrolyte-gated graphene field-effect transistors Journal Article

    ACS Sensors, 4 (2), pp. 286-293, 2019.

    Links | BibTeX

  • 2018

    Viviana Sousa José Rodrigues Francis Leonard Deepak Yohei Kakefuda Naoyuki Kawamoto Tetsuya Baba Bryan Owens-Baird Pedro Alpuim Kirill Kovnir Takao Mori Yury Kolen’ko V Marek Piotrowski Miguel Franco

    Probing of Thermal Transport in 50 nm Thick PbTe Nanocrystal Films by Time-Domain Thermoreflectance Journal Article

    Journal of Physical Chemistry C, 122 (48), pp. 27127–27134, 2018.

    Abstract | Links | BibTeX

    Yu Xu Amorim Gaspar Qiao Ferreira Alpuim Liu K J I J L P P L S. Mouli Thalluri J. Borme

    Conformal and continuous deposition of bifunctional cobalt phosphide layers on p-silicon nanowire arrays for improved solar hydrogen evolution Journal Article

    Nano Research, 11 (9), pp. 4823–4835, 2018, ISSN: 1998-0124.

    Abstract | Links | BibTeX

    Sitaramanjaneya Mouli Thalluri; Jérôme Borme; Dehua Xiong; Junyuan Xu; Wei Li; Isilda Amorim; Pedro Alpuim; João Gaspar; Hélder Fonseca; Liang Qiao; Lifeng Liu

    Highly-ordered silicon nanowire arrays for photoelectrochemical hydrogen evolution: An investigation on the effect of wire diameter, length and inter-wire spacing Journal Article

    Sustainable Energy & Fuels, 2 (5), pp. 978-982, 2018.

    Abstract | Links | BibTeX

    Igor Bdkin Ankor González-Mayorga Gonzalo Irurueta Helena Nogueira María Serrano Pedro Alpuim Paula A.A.P.Marques I S C Gil Gonçalves Jérôme Borme

    Reductive nanometric patterning of graphene oxide paper using electron beam lithography Journal Article

    Carbon, 129 , pp. 63-75, 2018.

    Links | BibTeX

    Cerqueira Borme Alpuim M F J P R. Campos G. Machado Jr.

    Wafer scale fabrication of graphene microelectrode arrays for the detection of DNA hybridization Journal Article

    Microelectronic Engineering, 189 , pp. 85-90, 2018.

    Links | BibTeX

  • 2017

    Rebouta Cerqueira Alpuim Barradas Alves L M F P N P E A. Al-Rjoub P. Costa

    Characterization of magnetron sputtered sub-stoichiometric CrAlSiNx and CrAlSiOyNx coatings Journal Article

    Surface and Coatings Technology, 328 , pp. 134-141, 2017.

    Links | BibTeX

    Wei Li Junjie Li Xiuli Fu Cerqueira Pedro Alpuim M F Dehua Xiong Qingqing Zhang and Lifeng Liu

    Atomic-layer-deposited ultrafine MoS2 nanocrystals on cobalt foam for efficient and stable electrochemical oxygen evolution Journal Article

    Nanoscale, 9 , pp. 2711-2717, 2017.

    Links | BibTeX

  • 2016

    Nogueira SS Goncalves Cerqueira MF Alpuim Tovar Rodriguez-Abreu Brezesinski Gomes AC Lucio Oliveira P J C G M Oliveira ACN

    Role of counter-ion and helper lipid content in the design and properties of nanocarrier systems: a biophysical study in 2D and 3D lipid assemblies Journal Article

    RSC Advances, 53 , pp. 47730-47740, 2016.

    Links | BibTeX

    Machado Jr. Cerqueira Freitas Zucolotto Peres G F P P V N M R N. C. S. Vieira J. Borme and P Alpuim

    Graphene field-effect transistor array with integrated electrolytic gates scaled to 200 mm Journal Article

    Journal of Physics: Condensed Matter, 28 , pp. 085302, 2016.

    Links | BibTeX

    Iglesias Machado Jr. V G P. Alpuim M. F. Cerqueira and J Borme

    Laser patterning of amorphous silicon thin films deposited on flexible and rigid substrates Journal Article

    physica status solidi (a), 213 (7), pp. 1717-1727, 2016.

    Links | BibTeX

    Ana Mestre Pedro Inácio Bragança Jérôme Borme George Machado Jr. Fátima Cerqueira Pedro Alpuim J Sanaz Asgarifa Henrique L. Gomes

    Electrochemically Gated Graphene Field-Effect Transistor for Extracellular Cell Signal Recording Conference

    Technological Innovation for Cyber-Physical Systems, 470 , Springer, Cham, 2016, ISBN: 978-3-319-31165-4.

    Links | BibTeX

  • 2015

    Tondelier Vanel Geffroy Bonnassieux Alpuim Bourée D J C B Y P J E S. Majee M.F. Cerqueira

    Permeation barrier performance of Hot Wire-CVD grown silicon-nitride films treated by argon plasma Journal Article

    Thin Solid Films, 575 , pp. 72-75, 2015.

    Links | BibTeX

    Tondelier Geffroy Bonnassieux Alpuim Bourée D B Y P J E S. Majee M.F. Cerqueira

    Flexible organic–inorganic hybrid layer encapsulation for organic opto-electronic devices Journal Article

    Progress in Organic Coatings, 80 , pp. 27-32, 2015.

    Links | BibTeX

    Rocha Alpuim Machado Baumann Lanceros-Méndez J G P A V R R S H.F. Castro E. Sowade

    Degradation of all-inkjet-printed organic thin-film transistors with TIPS-pentacene under processes applied in textile manufacturing Journal Article

    Organic Electronics, 22 , pp. 12-19, 2015.

    Links | BibTeX

    Pedro Alpuim Xiao-Qing Bao M. Fatima Cerqueira and Lifeng Liu

    Silicon Nanowire Arrays Coupled with Cobalt Phosphide Spheres as a Low-Cost Photocathode for Efficient Solar Hydrogen Evolution Journal Article

    Chemical Communications, 51 (53), pp. 10742-10745, 2015.

    Links | BibTeX

    Pedro Alpuim Daniel Stroppa Noelia Guldris Helder Fonseca Margaret Costa Joao Gaspar Chuanhong Jin Lifeng Liu G Xiao-Qing Bao Dmitri Y. Petrovykh

    Amorphous oxygen-rich molybdenum oxysulfide decorated p-type silicon microwire arrays for efficient photoelectrochemical water reduction Journal Article

    Nano Energy, 16 , pp. 130-142, 2015.

    Links | BibTeX

    Cerqueira Tondelier Geffroy Bonnassieux Bourée M F D B Y J E P. Alpuim S.Majee

    Effect of argon ion energy on the performance of silicon nitride multilayer permeation barriers grown by hot-wire CVD on polymers Journal Article

    Thin Solid Films, 595 , pp. 258-265, 2015.

    Links | BibTeX

  • 2014

    Tondelier Geffroy Bonnassieux Alpuim Bourée D B Y P J E S. Majee M.F. Cerqueira

    Influence of low energy argon plasma treatment on the moisture barrier performance of hot wire-CVD grown SiNx multilayers Journal Article

    Japanese Journal of Applied Physics, 53 (5S1), pp. 05FM05, 2014.

    Links | BibTeX

    Rebouta Alpuim Garcia Júnior Tavares L P C B G L C J M.V. Castro M.F. Cerqueira

    Influence of hydrogen plasma thermal treatment on the properties of ZnO:Al thin films prepared by dc magnetron sputtering Journal Article

    Vacuum, 107 , pp. 145, 2014.

    Links | BibTeX

  • 2013

    Martins Ribeiro Alpuim Rocha Morales Atienza Lanceros-Mendez M S C P J G I C S V. Correia V. Sencadas

    Piezoresistive sensors for force mapping of hip-prostheses Journal Article

    Sensors and Actuators A, 195 , pp. 133, 2013.

    Links | BibTeX

    Tondelier Geffroy Bonnassieux Alpuim Bourée D B Y P J E S. Majee M.F. Cerqueira

    The effect of argon plasma treatment on the permeation barrier properties of silicon nitride layers Journal Article

    Surface & Coatings Technology, 235 , pp. 361, 2013.

    Links | BibTeX

GROUP LEADER

Pedro-Alpoim-1_w

THE TEAM

Jérôme Borme
Staff Researcher

Alexandre Chícharo
Research Fellow

Andrea Capasso
Research Fellow

Sergey Tkachev
Research Engineer

Fátima Cerqueira
Scientific Associate at INL and an Assistant Professor at the Department of Physics of University of Minho, Braga

Balaji Sompalle
PhD student

Patrícia Cabral
PhD student

Ivo Colmiais
Ph.D. student

Vitor Silva
Ph.D. student

Telma Domingues
M.Sc. student

Teresa Rodrigues
M.Sc. student

Tiago Queirós
M.Sc. student

Lucas Silva
M.Sc. student

Lucas Baptista
M.Sc. student

Miguel Monteiro
Research Fellow

Fátima Cerqueira
Scientific Associate at INL and an Assistant Professor at the Department of Physics of University of Minho, Braga

Rui Campos
Research Fellow (2016-2017)

Tangyou Sun
Marie-Curie Cofund Research Fellow (2016-2017)

George Luiz Machado Junior
PhD Student Associate (2013-2016)

Nirton Cristi S. Vieira
INL Scientific Associate (2014-2015)

FORMER GROUP MEMBERS

Vishesh Saxena
INL Summer Student Internship (2018)

Saibal Mitra (Missouri State University, USA)
INL Scientific Associate (2018)

Daniela Ion-Ebrasu (National R&D Institute for Cryogenic and isotopic Technologies, Romania)
INL Scientific Associate (2018)

Jean-Eric Bourée (Ecole Polytechnique, France)
INL Scientific Associate (2018)

Reddithota Vidyasagar (UAveiro, Portugal)
INL Scientific Associate (2017)

Paulo Alexandre de Carvalho Gomes (IST, Portugal)
INL Master Student Associate (2017)

Renato Domingues
INL Summer Students Internship (2017)

Luis Quispe (University of Santa Catarina, Brazil)
INL- Cooperation Associate (2016-17)

Cédric Sebastien Martins Figueiredo (UMinho, Portugal)
INL Student Associate (2016)

Clarissa Towle (MIT, USA)
MIT-Portugal INL Summer Students Internship (2015)

Alexandre Faia de Carvalho (UAveiro, Portugal)
INL Master Student Associate (2015)

Helder Xavier Pereira Peixoto (UMinho, Portugal)
INL Student Associate (2013)

César Rui de Freitas Bernardo
INL Summer Students Internship (2012)

César Rui de Freitas Bernardo
INL Summer Students Internship (2012)

Subimal Majee (Ecole Polytechnique, France)
INL PhD Student Associate (2012)