Carole Sousa is a Research Fellow in the Nanodevices Research Group. Her work aims the development of a HCV diagnostic system for viral particles detection using an integrated lab-on chip platform.

Carole graduated in Applied Biology and completed her MSc in Molecular Genetics (2012) from the University of Minho (Portugal). She holds a PhD in Biology (2018) from the University of Luxembourg. Her doctoral research was focused on the understanding of the specific molecular triggers and the subsequent genetic programmes defining microglia under homeostatic, inflammatory and neurodegenerative conditions, using high-throughput single-cell transcriptomics. During her postdoc in Germany, her major focus was the understanding of proper macrophage homeostasis in the brain.

• Sousa C, Golebiewska A, Poovathingal SK, Kaoma T, Pires-Afonso Y, Martina S, Coowar D, Azuaje F, Skupin A, Balling R, Biber K, Niclou SP, Michelucci A.
  Single-cell transcriptomics reveals distinct inflammation-induced microglia signatures
  EMBO Rep. 2018 Nov;19(11):e46171. doi: 10.15252/embr.201846171. Epub 2018 Sep 11. PMID: 30206190 Free PMC article.

• Cordes T, Wallace M, Michelucci A, Divakaruni AS, Sapcariu SC, Sousa C, Koseki H, Cabrales P, Murphy AN, Hiller K, Metallo CM.
  Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels
  J Biol Chem. 2016 Jul 1;291(27):14274-14284. doi: 10.1074/jbc.M115.685792. Epub 2016 May 9. PMID: 27189937 Free PMC article.

• Sousa C, Biber K, Michelucci A.
  Cellular and Molecular Characterization of Microglia: A Unique Immune Cell Population
  Front Immunol. 2017 Mar 2;8:198. doi: 10.3389/fimmu.2017.00198. eCollection 2017. PMID: 28303137 Free PMC article. Review.

• Carmona J, Cruz A, Moreira-Teixeira L, Sousa C, Sousa J, Osorio NS, Saraiva AL, Svenson S, Kallenius G, Pedrosa J, Rodrigues F, Castro AG, Saraiva M.
  Mycobacterium tuberculosis Strains Are Differentially Recognized by TLRs with an Impact on the Immune Response.
  PLoS One. 2013 Jun 26;8(6):e67277. doi: 10.1371/journal.pone.0067277. Print 2013. PMID: 23840651 Free PMC article.

• Teixeira-Coelho M, Cruz A, Carmona J, Sousa C, Ramos-Pereira D, Saraiva AL, Veldhoen M, Pedrosa J, Castro AG, Saraiva M.
  TLR2 deficiency by compromising p19 (IL-23) expression limits Th 17 cell responses to Mycobacterium tuberculosis.
  Int Immunol. 2011 Feb;23(2):89-96. doi: 10.1093/intimm/dxq459. Epub 2010 Dec 14. PMID: 21156751