Milene Silva

Research Fellow

Milene Costa da Silva is a Research Fellow in the Nanomedicine group of the Nano4Health unit, Department of Life Sciences. Her research focuses on the development and validation of a nanoparticle-based drug delivery system to be used in cancer therapy.

Milene received her PhD in Basic and Applied Biology from the University of Porto, Portugal, and the University of Heidelberg, Germany. During her PhD, she discovered that treating several types macrophages with different sources of iron (including iron-oxide nanoparticles), modulates macrophages towards a pro-inflammatory M1-like polarization. Additionally, she was able to show that loading of tumor-associated macrophages with iron-oxide nanoparticles contributes to tumor cell death and impairment of tumor growth.

Selected Publications

  • Costa da Silva, M., Breckwoldt, M.O., Vinchi, F., Correia, M.P., Stojanovic, A., Thielmann, C.M., Meister, M., Muley, T., Warth, A., Platten, M., Hentze, M.W., Cerwenka, A., and Muckenthaler, M.U. (2017).
    Iron Induces Anti-tumor Activity in Tumor-Associated Macrophages
    Frontiers in immunology 8, 1479 DOI: 10.3389/fimmu.2017.01479
  • Zenatti, P.P., Ribeiro, D., Li, W., Zuurbier, L., Silva, M.C., Paganin, M., Tritapoe, J., Hixon, J.A., Silveira, A.B., Cardoso, B.A., Sarmento, L.M., Correia, N., Toribio, M.L., Kobarg, J., Horstmann, M., Pieters, R., Brandalise, S.R., Ferrando, A.A., Meijerink, J.P., Durum, S.K., Yunes, J.A., and Barata, J.T. (2011).
    Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia
    Nature genetics 43, 932-939 DOI: 10.1038/ng.924