Murali Kumarasamy

Research Fellow
Precision Medicine Engineering

Murali (MS, PhD) joined Precision Medicine Engineering group at the International Iberian Nanotechnology Laboratory in November 2019 as Research Fellow. His current interdisciplinary research focuses on developing ‘personalized’ solutions that utilize micro-and nanoscale technologies to enable a range of theranostics for neurodegenerative diseases and cancer.

The underpinning focus of Murali´s research is creating novel approaches for delivering drugs across complex barriers in the body such as the neurovascular blood-brain barrier, nose-to brain and the intestine model systems. This is reflected in his peer-reviewed publications, and in the authorship of invited book chapters.

After graduating in Pharmaceutical Sciences and Nanobiotechnology, Murali undertook a PhD in Theoretical Medicine at the Laboratory of Cellular and Developmental Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, where he has joined the far larger multidisciplinary European Commission FP7 Marie Curie consortium of NanoTOES and his interdisciplinary doctoral thesis investigated the “Interaction of Nanoparticles with neural stem-and tissue-type cells”. Since completing his PhD in 2015 Murali has held numerous post-doctoral positions in India and abroad; working in multidisciplinary aspects and he has gained valuable experience in testing biological responses to nanoparticles and nanomaterials.

Selected Publications

  • Murali Kumarasamy, and Alejandro Sosnik
    The Nose‐To‐Brain Transport of Polymeric Nanoparticles Is Mediated by Immune Sentinels and Not by Olfactory Sensory Neurons
    Advanced Biosystems 2019, 1900123
  • Chauhan Prakram Singh, Murali Kumarasamy, Alejandro Sosnik, and Dganit Danino
    Enhanced thermostability and anticancer activity in breast cancer cells, of laccase immobilized on Pluronic®-stabilized nanoparticles
    ACS Appl. Mater. Interfaces 2019, 11, 43, 39436-39448
  • Zaritski, Anna, Helena Castillo-Ecija, Murali Kumarasamy, Ella Peled, Roni Sverdlov Arzi, Ángel M. Carcaboso, and Alejandro Sosnik
    Selective Accumulation of Galactomannan Amphiphilic Nanomaterials in Pediatric Solid Tumor Xenografts Correlates with GLUT1 Gene Expression
    ACS applied materials & interfaces 2019, 11, 42, 38483-38496.
  • K.Murali, K Kenesei, Yang Li, K. Demeter, Zs. Környei, Madarasz Emilia
    Uptake and bio-reactivity of polystyrene nanoparticles is affected by surface modifications, ageing and LPS adsorption: in vitro studies on neural tissue cells
    Nanoscale, 2015, 7, 4199 – 4210
  • Kumarasamy Murali, Sosnik Alejandro
    A multicelular three-dimensional (3D) in vitro model of the neurovascular blood-brain barrier: Towards a new platform for evaluating nanoparticle as vehicles for precision nano-neuromedicine
    (Under-review, 2019)