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Nanodevices

RESEARCH

DEPARTMENTS
Nanoelectronics engineering
RESEARCH GROUPS
SystemsEngineerings
nanodevices
spintronics
BTN_PME

DESCRIPTION

The nanodevices group develops integrated sensor solutions for the biomedical, food and environment areas, as well as industrial sensing applications. In the biomedical sensor area, magnetoresistive based protein or DNA chips, and magnetoresistive cytometers (technologies previously developed at INESC MN-Lisbon), are now being tested in different clinical applications. The bioanalyte is labelled with a magnetic nanoparticle or bead, through an intervenient antibody, aptamer, complementary DNA strand, and after recognition, the signal is read in the magnetoresistive sensor array. Label-free technologies are also being developed, using direct molecular fingerprinting of compounds and molecules using microfluidics, an optical detection, starting with discrete assembly of pre-existent modules (microfluidic reactor, light source, optical spectrometer) to the full integration of components at the wafer level in collaboration with partners. The group (together with the spintronics group) is actively involved on the prototyping of tunnel magnetoresistive based sensors for industrial applications.

RESEARCH PROJECTS

Project INVENNTA II (in collaboration with the neuroscience group of J Castillo, at IDIS-H Universitario de Santiago de Compostela)

Team: INL ( Elizabete Fernandes, P.P.Freitas)

           IDIS, T Sobrino, J Castillo

          Other collaborators:  S Cardoso, and T.Dias at INESC MN, under subcontract, supplying MR chip technology

project 1

Platforms, PCBs, and magnetoresistive chips, being used for the multiplexed detection of ischemic stroke patient biomarkers

Conference presentation: Fernandes E., Martins V., Dias T., Germano J., Sobrino T., Cardoso S., Castillo J., Rivas J., Freitas PP. Simultaneous interrogation of multiple targets using a magnetoresistive (MR) biochip platform. Biosensors 2016, Gothenburg, Sweden 25-27 May 2016

Project INVENNTA II (in collaboration with the oncology group of R. Lopez, at IDIS-H Universitario de Santiago de Compostela)

Team: INL ( Alexandre Chicharo, P.P.Freitas, L Dieguez, B.Espina, M.Martins, J.Piteira)

            IDIS, R Lopez

            Other collaborators: S Cardoso at INESC MN, supplying MR cytometer chips

Cell labelled with magnetic beads

Cell labelled with magnetic beads


MR cytometer PCB, with integrated microfluidics and sensors

MR cytometer PCB, with integrated microfluidics and sensors

Conference presentation: A. Chícharo, M. Martins, B. Espiña, S. Cardoso and P. Freitas, High-throughput magnetic flow cytometer for tumour cell quantification, 13th Joint MMM-Intermag Conference, January 11-15, 2016, San Diego, California, US.

Exploiting spin transfer based nano-oscillators and spin Hall devices. Inl hosts one PhD student ( Mohammad Tarequzzaman) and has hosted one post doctoral fellow ( Bertrand Lacoste) with joint co-advising from Ricardo Ferreira (Spintronics), and P.Freitas. (more details in the spintronics group site).

This project is based on a COFUND fellowship holder ( Hongyan Bi) and addresses the specific, accurate, and fast quantification through optical means of compounds within a complex matrix background.

Schematic illustration of the microfluidic sensor integrated with after-channel UV/vis spectrophotometric detection for food ingredient analysis. (b) Collected absorbance change at 266 nm of solutions containing only caffeine, and mixture of AA and caffeine before (A0) and after (A) passing through the enzyme-loaded microfluidic sensor at 5 μL/min. Arrows indicate the time when it is started to sample the solution through the microfluidic channel.

Schematic illustration of the microfluidic sensor integrated with after-channel UV/vis spectrophotometric detection for food ingredient analysis. (b) Collected absorbance change at 266 nm of solutions containing only caffeine, and mixture of AA and caffeine before (A0) and after (A) passing through the enzyme-loaded microfluidic sensor at 5 μL/min. Arrows indicate the time when it is started to sample the solution through the microfluidic channel.

Publication: H. Bi, A. C. Fernandes, S. Cardoso and P. Freitas, Interference-Blind Microfluidic Sensor for Ascorbic Acid Determination by UV/vis Spectroscopy. Sensors and Actuators B: Chemical, 2016, 224, 668-675.

Starting project in collaboration with the Systems Engineering group, and external partners, to develop a fully integrated microspectrometer using CMOS based or a-Si:H based photodiodes, thin film multilayer band pass filters, and LEDS, into a compact format suitable for integration with control and communication hardware for a portable solution.

This project is being developed within the PhD thesis of M.Costa ( NanoFab). The goal is to incorporate magnetoresistive sensors with typical features of 100nm on the tip of AFM cantilevers, providing direct field mapping through an AFM probe.

Resonance characterization of the cantilever with a resonance frequency of ∼250 kHz. (b) Voltage output versus the external applied magnetic field response of an individualSV sensor already integrated in an AFM cantilever.

Resonance characterization of the cantilever with a resonance frequency of ∼250 kHz. (b) Voltage output versus the external applied magnetic field response of an individualSV sensor already integrated in an AFM cantilever.

Publication: “Integration of magnetoresistive sensors with atomic force microscopy cantilevers for scanning magnetoresistance microscopy applications”, M. Costa, J. Gaspar, R. Ferreira, E. Paz, H. Fonseca, M. Martins, S. Cardoso, and P. P. Freitas, IEEE Trans. Magnetics, vol. 51, no. 11, pp. 6503104, Nov. 2015

PUBLICATIONS

57 entries « 2 of 2 »

2013

Liebing, N; Serrano-Guisan, S; Krzysteczko, P; Rott, K; Reiss, G; Langer, J; Ocker, B; Schumacher, H W

Tunneling magneto thermocurrent in CoFeB/MgO/CoFeB based magnetic tunnel junctions Journal Article

Applied Physics Letters, 102 (24), pp. 242413, 2013.

Links | BibTeX

2012

Arias, S; Munoz, D; Moreno, J; Cardoso, S; Ferreira, R; Freitas, P P

Fractional Modeling of the AC Large-Signal Frequency Response in Magnetoresistive Current Sensors Journal Article

Sensors, 13 (12), pp. 17516-17533, 2012.

Links | BibTeX

Ventura, J; Teixeira, J M; Paz, E; Amaral, J S; Costa, J D; Araujo, J P; Cardoso, S; Ferreira, R; Freitas, P P

The influence of annealing on the bimodal distribution of blocking temperatures of exchange biased bilayers Journal Article

Phys. Status Solidi RRL, 7 (9), pp. 676-680, 2012.

BibTeX

Ferreira, R; Paz, E; Freitas, P P; Wang, J; Xue, S

Large Area and Low Aspect Ratio Linear Magnetic Tunnel Junctions with a Soft-Pinned Sensing Layer Journal Article

IEEE Trans. Magn, 48 (11), pp. 3719, 2012.

Links | BibTeX

Ferreira, R; Paz, E; Freitas, P P; Ribeiro, J; Germano, J; Sousa, L

2-axis Magnetometers Based on Full Wheatstone Bridges Incorporating Magnetic Tunnel Junctions Connected in Series Journal Article

IEEE Trans. Magn, 48 (11), pp. 4107, 2012.

Links | BibTeX

Sanchez, J; Ramirez, D; Ravelo, S; Lopes, A; Cardoso, S; Ferreira, R; Freitas, P P

Electrical Characterization of a Magnetic Tunnel Junction Current Sensor for Industrial Applications Journal Article

IEEE Trans. Magn, 48 (11), pp. 2823, 2012.

Links | BibTeX

Janeiro, R J; Gameiro, L; Lopes, A; Cardoso, S; Ferreira, R; Paz, E; Freitas, P P

Linearization and Field Detectivity in Magnetic Tunnel Junction Sensors Connected in Series Incorporating 16nm-thick NiFe Free Layers Journal Article

IEEE Trans. Magn, 48 (11), pp. 4111, 2012.

Links | BibTeX

57 entries « 2 of 2 »

GROUP LEADER

Paulo Freitas - 1

THE TEAM

Elisabete Fernandes
Staff researcher

Hugo Oliveira
Staff researcher

Peng Weng Kung
Group Leader

Chun-Da Liao
Research Fellow

Filipe Alves
Research Fellow

Denis Santos
Research Fellow

Cosimo Spagnolo
Research Engineer

Mariana Carvalho
Research Engineer

Mohamed Belmoubarik
Research Engineer

Carla Carvalho
Research Fellow

Magdalena Lepicka
Research Fellow

Milan Obradovic
Research Fellow

Purushottam Joshi
Research Fellow

Andrea Cruz
Research Fellow

Sandra Carvalho
Research Fellow

Diana Pinho
Research Fellow

Miguel Amaral
Master student (U Porto)

DESCRIPTION

The nanodevices group develops integrated sensor solutions for the biomedical, food and environment areas, as well as industrial sensing applications. In the biomedical sensor area, magnetoresistive based protein or DNA chips, and magnetoresistive cytometers (technologies previously developed at INESC MN-Lisbon), are now being tested in different clinical applications. The bioanalyte is labelled with a magnetic nanoparticle or bead, through an intervenient antibody, aptamer, complementary DNA strand, and after recognition, the signal is read in the magnetoresistive sensor array. Label-free technologies are also being developed, using direct molecular fingerprinting of compounds and molecules using microfluidics, an optical detection, starting with discrete assembly of pre-existent modules (microfluidic reactor, light source, optical spectrometer) to the full integration of components at the wafer level in collaboration with partners. The group (together with the spintronics group) is actively involved on the prototyping of tunnel magnetoresistive based sensors for industrial applications.

RESEARCH PROJECTS

Project INVENNTA II (in collaboration with the neuroscience group of J Castillo, at IDIS-H Universitario de Santiago de Compostela)

Team: INL ( Elizabete Fernandes, P.P.Freitas)

           IDIS, T Sobrino, J Castillo

          Other collaborators:  S Cardoso, and T.Dias at INESC MN, under subcontract, supplying MR chip technology

project 1

Platforms, PCBs, and magnetoresistive chips, being used for the multiplexed detection of ischemic stroke patient biomarkers

Conference presentation: Fernandes E., Martins V., Dias T., Germano J., Sobrino T., Cardoso S., Castillo J., Rivas J., Freitas PP. Simultaneous interrogation of multiple targets using a magnetoresistive (MR) biochip platform. Biosensors 2016, Gothenburg, Sweden 25-27 May 2016

Project INVENNTA II (in collaboration with the oncology group of R. Lopez, at IDIS-H Universitario de Santiago de Compostela)

Team: INL ( Alexandre Chicharo, P.P.Freitas, L Dieguez, B.Espina, M.Martins, J.Piteira)

            IDIS, R Lopez

            Other collaborators: S Cardoso at INESC MN, supplying MR cytometer chips

Cell labelled with magnetic beads

Cell labelled with magnetic beads


MR cytometer PCB, with integrated microfluidics and sensors

MR cytometer PCB, with integrated microfluidics and sensors

Conference presentation: A. Chícharo, M. Martins, B. Espiña, S. Cardoso and P. Freitas, High-throughput magnetic flow cytometer for tumour cell quantification, 13th Joint MMM-Intermag Conference, January 11-15, 2016, San Diego, California, US.

Exploiting spin transfer based nano-oscillators and spin Hall devices. Inl hosts one PhD student ( Mohammad Tarequzzaman) and has hosted one post doctoral fellow ( Bertrand Lacoste) with joint co-advising from Ricardo Ferreira (Spintronics), and P.Freitas. (more details in the spintronics group site).

This project is based on a COFUND fellowship holder ( Hongyan Bi) and addresses the specific, accurate, and fast quantification through optical means of compounds within a complex matrix background.

Schematic illustration of the microfluidic sensor integrated with after-channel UV/vis spectrophotometric detection for food ingredient analysis. (b) Collected absorbance change at 266 nm of solutions containing only caffeine, and mixture of AA and caffeine before (A0) and after (A) passing through the enzyme-loaded microfluidic sensor at 5 μL/min. Arrows indicate the time when it is started to sample the solution through the microfluidic channel.

Schematic illustration of the microfluidic sensor integrated with after-channel UV/vis spectrophotometric detection for food ingredient analysis. (b) Collected absorbance change at 266 nm of solutions containing only caffeine, and mixture of AA and caffeine before (A0) and after (A) passing through the enzyme-loaded microfluidic sensor at 5 μL/min. Arrows indicate the time when it is started to sample the solution through the microfluidic channel.

Publication: H. Bi, A. C. Fernandes, S. Cardoso and P. Freitas, Interference-Blind Microfluidic Sensor for Ascorbic Acid Determination by UV/vis Spectroscopy. Sensors and Actuators B: Chemical, 2016, 224, 668-675.

Starting project in collaboration with the Systems Engineering group, and external partners, to develop a fully integrated microspectrometer using CMOS based or a-Si:H based photodiodes, thin film multilayer band pass filters, and LEDS, into a compact format suitable for integration with control and communication hardware for a portable solution.

This project is being developed within the PhD thesis of M.Costa ( NanoFab). The goal is to incorporate magnetoresistive sensors with typical features of 100nm on the tip of AFM cantilevers, providing direct field mapping through an AFM probe.

Resonance characterization of the cantilever with a resonance frequency of ∼250 kHz. (b) Voltage output versus the external applied magnetic field response of an individualSV sensor already integrated in an AFM cantilever.

Resonance characterization of the cantilever with a resonance frequency of ∼250 kHz. (b) Voltage output versus the external applied magnetic field response of an individualSV sensor already integrated in an AFM cantilever.

Publication: “Integration of magnetoresistive sensors with atomic force microscopy cantilevers for scanning magnetoresistance microscopy applications”, M. Costa, J. Gaspar, R. Ferreira, E. Paz, H. Fonseca, M. Martins, S. Cardoso, and P. P. Freitas, IEEE Trans. Magnetics, vol. 51, no. 11, pp. 6503104, Nov. 2015

PUBLICATIONS

57 entries « 2 of 2 »

2013

Liebing, N; Serrano-Guisan, S; Krzysteczko, P; Rott, K; Reiss, G; Langer, J; Ocker, B; Schumacher, H W

Tunneling magneto thermocurrent in CoFeB/MgO/CoFeB based magnetic tunnel junctions Journal Article

Applied Physics Letters, 102 (24), pp. 242413, 2013.

Links | BibTeX

2012

Arias, S; Munoz, D; Moreno, J; Cardoso, S; Ferreira, R; Freitas, P P

Fractional Modeling of the AC Large-Signal Frequency Response in Magnetoresistive Current Sensors Journal Article

Sensors, 13 (12), pp. 17516-17533, 2012.

Links | BibTeX

Ventura, J; Teixeira, J M; Paz, E; Amaral, J S; Costa, J D; Araujo, J P; Cardoso, S; Ferreira, R; Freitas, P P

The influence of annealing on the bimodal distribution of blocking temperatures of exchange biased bilayers Journal Article

Phys. Status Solidi RRL, 7 (9), pp. 676-680, 2012.

BibTeX

Ferreira, R; Paz, E; Freitas, P P; Wang, J; Xue, S

Large Area and Low Aspect Ratio Linear Magnetic Tunnel Junctions with a Soft-Pinned Sensing Layer Journal Article

IEEE Trans. Magn, 48 (11), pp. 3719, 2012.

Links | BibTeX

Ferreira, R; Paz, E; Freitas, P P; Ribeiro, J; Germano, J; Sousa, L

2-axis Magnetometers Based on Full Wheatstone Bridges Incorporating Magnetic Tunnel Junctions Connected in Series Journal Article

IEEE Trans. Magn, 48 (11), pp. 4107, 2012.

Links | BibTeX

Sanchez, J; Ramirez, D; Ravelo, S; Lopes, A; Cardoso, S; Ferreira, R; Freitas, P P

Electrical Characterization of a Magnetic Tunnel Junction Current Sensor for Industrial Applications Journal Article

IEEE Trans. Magn, 48 (11), pp. 2823, 2012.

Links | BibTeX

Janeiro, R J; Gameiro, L; Lopes, A; Cardoso, S; Ferreira, R; Paz, E; Freitas, P P

Linearization and Field Detectivity in Magnetic Tunnel Junction Sensors Connected in Series Incorporating 16nm-thick NiFe Free Layers Journal Article

IEEE Trans. Magn, 48 (11), pp. 4111, 2012.

Links | BibTeX

57 entries « 2 of 2 »

GROUP LEADER

blank-male

THE TEAM

Elisabete Fernandes
Staff researcher

Hugo Oliveira
Staff researcher

Alexandre Chicharo
PhD student (IST)

Miguel Amaral
Master student (U Porto)

RESEARCH

Nanoelectronics engineering
DEPARTMENTS
RESEARCH GROUPS
SystemsEngineerings
nanodevices
spintronics
BTN_PME