Medical Devices
The Medical Devices group is dedicated to translational medical research in close collaboration with hospitals. We focus on the development of tools and solutions based on microfluidics, biosensors and nanotechnology towards early diagnosis and better understanding of diseases.
Research lines:
- Non-invasive disease monitoring (biomicrofluidic systems to isolate disease biomarkers from body fluids)
- Early and accurate disease diagnosis (nanobiosensors to study and evaluate disease biomarkers)
- Disease modelling (biomimetic 3D organ-on-a-chip systems to model processes in disease evolution and treatment)
- Medical instrumentation technology development
Projects
Publications
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Recent Advances in Cell-Based In Vitro Models to Recreate Human Intestinal Inflammation
ADVANCED SCIENCE, 2023Development of Smart Clothing to Prevent Pressure Injuries in Bedridden Persons and/or with Severely Impaired Mobility: 4NoPressure Research Protocol
Healthcare 2023, 11(10), 1361; https://doi.org/10.3390/healthcare11101361 , 2023From mouth to gut: microfluidic in vitro simulation of human gastro-intestinal digestion and intestinal permeability
ANALYST, 2023Current and Emerging Techniques for Diagnosis and MRD Detection in AML: A Comprehensive Narrative Review
CANCERS, 2023Clinical Validation of a Size-Based Microfluidic Device for Circulating Tumor Cell Isolation and Analysis in Renal Cell Carcinoma
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023Self-Powered Flexible Piezoelectret Array for Wearable Applications
2023 IEEE 36TH INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS, MEMS, 2023A microfluidic platform combined with bacteriophage receptor binding proteins for multiplex detection of Escherichia coli and Pseudomonas aeruginosa in blood
Sensors and Actuators B: Chemical, 2023End-users assessment of an innovative clothing-based sensor developed for pressure injury prevention: a mixed-method study
International Journal of Environmental Research and Public Health, 2023Will data analytics revolution finally bring SERS to the clinic?
TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 2023A portable Surface-Enhanced Raman Spectroscopy platform for biofluid analysis
TRANSLATIONAL BIOPHOTONICS: DIAGNOSTICS AND THERAPEUTICS III, 2023An innovative platform to mimic the tumoral vascular microenvironment (TME) of patients with metastatic colorectal cancer (mCRC) using bioprinted hydrogel microfluidics
Cancer Res (2023) 83 (7_Supplement): 4577, 2023 -
Advances in Microfluidics for the Implementation of Liquid Biopsy in Clinical Routine
Microfluidics and Biosensors in Cancer Research pp 553–590, 2022Evolution in Automatized Detection of Cells: Advances in Magnetic Microcytometers for Cancer Cells
Springer International Publishing, 2022Portable electroanalytical nucleic acid amplification tests using printed circuit boards and open-source electronics
ANALYST, 2022Surface enhanced Raman spectroscopy for tumor nucleic acid: Towards cancer diagnosis and precision medicine
BIOSENSORS & BIOELECTRONICS, 2022Label-free SERS techniques in biomedical applications
SERS for Point-of-care and Clinical Applications (ELSEVIER), 2022Establishing an expert consensus on key indicators of quality of life among breast cancer survivors: a modified Delphi study
Journal of Clinical Medicine 2022, 11 (7), 2041, 2022 -
Use of some cost-effective technologies for a routine clinical pathology laboratory
LAB ON A CHIP, 2021Correlative atomic force microscopy
Published May 2021 • Copyright © IOP Publishing Ltd 2021 Pages III.1.b-1 to III.1.b-13, 2021Single-use microfluidic device for purification and concentration of environmental DNA from river water
TALANTA, 2021Electrochemical Sensing in 3D Cell Culture Models: New Tools for Developing Better Cancer Diagnostics and Treatments
CANCERS, 2021Performance assessment of 11 commercial serological tests for SARS-CoV-2 on hospitalised COVID-19 patients
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2021A novel microfluidic system for the sensitive and cost-effective detection of okadaic acid in mussels
ANALYST, 2021Dynamics of Fractal Ruptures in Biomembranes
BIOPHYSICAL JOURNAL, 2021Front Cover of the article Fluorescence cross-correlation spectroscopy as a valuable tool to characterize cationic liposome-DNA nanoparticle assembly
Journal of Biophotonics - First published: 04 January 2021, 2021How did correlative atomic force microscopy and super-resolution microscopy evolve in the quest for unravelling enigmas in biology?
NANOSCALE, 2021Subcompartmentalization and Pseudo‐Division of Model Protocells
Small, 2021Inside back cover - Showcasing a collaborative review work between the laboratory of Dr Pieter De Beule with Dr Andreas Stylianou, Dr Liisa Hirvonen and Dr Humberto Sánchez. How did correlative atomic force microscopy and super- resolution microscopy evolve in the quest for unravelling enigmas in biology?
Nanoscale, 2021,13, 2729-2729 , 2021Target Score-A Proteomics Data Selection Tool Applied to Esophageal Cancer Identifies GLUT1-Sialyl Tn Glycoforms as Biomarkers of Cancer Aggressiveness
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021Enhanced virtual reality application with tactile feedback for prototyping in-car dashboard surfaces
2021 IEEE WORLD HAPTICS CONFERENCE (WHC), 2021Multiplexing Liquid Biopsy with Surface-Enhanced Raman Scattering Spectroscopy
ADVANCED OPTICAL MATERIALS, 2021Correlative laser free confocal and atomic force microscopy
Application note with Aurox, 2021 -
Phenotypic Analysis of Urothelial Exfoliated Cells in Bladder Cancer via Microfluidic Immunoassays: Sialyl-Tn as a Novel Biomarker in Liquid Biopsies
FRONTIERS IN ONCOLOGY, 2020A SERS-based 3D nanobiosensor: towards cell metabolite monitoring
MATERIALS ADVANCES, 2020Comparability of Raman Spectroscopic Configurations: A Large Scale Cross-Laboratory Study
ANALYTICAL CHEMISTRY, 2020Encapsulation of Nanostructures in a Dielectric Matrix Providing Optical Enhancement in Ultrathin Solar Cells
SOLAR RRL, 2020Fluorescencecross-correlationspectroscopy as a valuable tool to characterize cationicliposome-DNAnanoparticle assembly
JOURNAL OF BIOPHOTONICS, 2020Facile synthesis of an aminopropylsilane layer on Si/SiO2 substrates using ethanol as APTES solvent
METHODSX, 2020A smart microfluidic platform for rapid multiplexed detection of foodborne pathogens
FOOD CONTROL, 2020Circulating Tumour Cells: A Portuguese contribution towards Precision Medicine
Revista Portuguesa de Cirurgia (2020) 47: 23-29, 2020In Vitro Evaluation of Lipopolyplexes for Gene Transfection: Comparing 2D, 3D and Microdroplet-Enabled Cell Culture
MOLECULES, 2020Raman Spectroscopy for Tumor Diagnosis in Mammary Tissue
PROCEEDINGS OF THE 8TH INTERNATIONAL CONFERENCE ON PHOTONICS, OPTICS AND LASER TECHNOLOGY (PHOTOPTICS), 2020Correlative fluorescence and atomic force microscopy to advance the bio-physical characterisation of co-culture of living cells
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2020 -
Gold Nanostars for the Detection of Foodborne Pathogens via Surface-Enhanced Raman Scattering Combined with Microfluidics
ACS APPLIED NANO MATERIALS, 2019Amplification-free SERS analysis of DNA mutation in cancer cells with single-base sensitivity
NANOSCALE, 2019Exploring sialyl-Tn expression in microfluidic-isolated circulating tumour cells: A novel biomarker and an analytical tool for precision oncology applications
NEW BIOTECHNOLOGY, 2019Fast and efficient microfluidic cell filter for isolation of circulating tumor cells from unprocessed whole blood of colorectal cancer patients
SCIENTIFIC REPORTS, 2019Microfluidics-Driven Fabrication of a Low Cost and Ultrasensitive SERS-Based Paper Biosensor
APPLIED SCIENCES-BASEL, 2019Portable sensing system based on electrochemical impedance spectroscopy for the simultaneous quantification of free and total microcystin-LR in freshwaters
BIOSENSORS & BIOELECTRONICS, 2019The Significance of Circulating Tumour Cells in the Clinic
ACTA CYTOLOGICA, 2019