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July 23, 2024

Researchers Inspire Young Minds at Schools

Filipa Lebre: Exploring the Frontier of Nanosafety

Filipa Lebre is a Research Fellow in the Nanosafety Research Group at INL, and her research focuses on the complex interactions among the immunological system and different organs, using novel technologies and in-house developed systems. Filipa has a background in Pharmaceutical Sciences and holds a PhD in Pharmaceutical Technology from the Faculty of Pharmacy, University of Coimbra, focused on the development and optimization of a polymeric nasal vaccine against hepatitis B to be used for mass immunization. She moved to Ireland during her postdoc to conduct her research at the interface between biomaterial and immunology, studying key aspects of immunomodulation by a relevant spectrum of materials with applicability in the regenerative medicine field. Could you share with us your professional trajectory and what inspired you to embark on a career in nanosafety? I’m very curious by nature and always had this passion and interest in science. When I did my degree in Pharmaceutical Science, I was fortunate enough to find a teacher who was working in the vaccine field and made me realize how I could use my passion to impact millions of lives. That was when I started to work with nanoformulations. I obtained my PhD in formulation development, […]

Can we cut the energy consumption of current AI technologies?

As artificial intelligence, commonly referred to as AI, becomes increasingly integrated into various aspects of our daily lives, the energy demands of AI systems continue to rise. Despite AI being inspired by the human brain, it is significantly less energy efficient because most tasks are implemented on computer hardware that is not specifically tailored for this purpose. The human brain remains an exemplar of energy-efficient computation, a standard that modern technology strives to replicate. INL researchers are studying advanced materials and devices aimed at revolutionising AI systems. Carlos Rosário, ERA fellow at INL (Marie Skłodowska-Curie actions (MSCA)), focuses his research on reducing the substantial energy consumption required by current AI technologies. Carlos’ work is grounded in the field of neuromorphic computing, which seeks to mimic the brain’s intricate network of neurons and synapses using artificial equivalents. The goal is to create an electronic brain capable of performing complex computations with minimal energy use. One of the key areas of Carlos Rosário’s research is the exploration of 3D topological insulators for novel electronic devices. These cutting-edge materials exhibit unique properties: while they are insulators and do not conduct electricity through their bulk, their surfaces behave like metals, allowing for efficient electrical […]

Secretary of State for Science Visits INL, Showcasing Key Projects and Innovations

Prof. Dr Ana Paiva, Secretary of State for Science, visited INL – International Iberian Nanotechnology Laboratory today. This visit provided an exceptional platform for INL to present its ongoing projects and significant achievements in the field of science and technology. The presence of Prof. Dr. Paiva underscored the crucial role of INL’s work and its far-reaching impact on the broader scientific community. Prof. Dr. Clivia M. Sotomayor Torres, INL Director-General, welcomed Prof. Dr Paiva and provided an insightful overview of INL’s mission and accomplishments. This introduction set the stage for a series of detailed presentations and discussions that highlighted INL’s prominence in both the national and European research landscapes. Presentation Highlights: Secretary of State’s visit to INL was a testament to the laboratory’s dedication to innovation, excellence, and its significant contributions to the field of science and technology. This visit not only highlighted INL’s achievements but also reinforced the importance of continued support and investment in scientific research and development. Text and Photography by Gina Palha

Breakthrough technology for cancer diagnostics

INL researchers are part of the consortium behind BIOCELLPHE, a pioneering project focused on advancing cancer diagnostics and personalised medicine. This innovative European-funded project is at the forefront of scientific and technological innovation, introducing a groundbreaking technology for identifying proteins as diagnostic biomarkers at the single-cell level. This new approach offers multiplexing capabilities, portability and enhanced sensitivity. Alexandra Teixeira, research fellow at the Medical Devices group, highlights that “BIOCELLPHE is pioneering the use of engineered bacteria to recognise and bind with high specificity to protein targets on the surface of circulating tumour cells, or CTCs, which are key players in cancer metastasis.” This specific binding of engineered bacteria to CTCs subsequently triggers the production of molecules (Raman reporters), which can be detectable with high sensitivity using surface-enhanced Raman scattering (SERS). More specifically, SERS uses plasmonic nanoparticles to enhance Raman signals, allowing ultrasensitive analysis and detection at the single molecule level. The pathological role of CTCs in cancer metastasis is not completely understood due to the lack of effective analytical tools and remains an area that needs further exploration. BIOCELLPHE addresses this gap by developing new tools for the phenotypic identification of CTCs at the single-cell level, with high-throughput and multiplexing […]

INL’s Official Mourning Day in honour of Manuel Cargaleiro

The Portuguese Government declared today, July 2nd, a National Day of Mourning in honour of Manuel Cargaleiro. The mourning coincides with the funeral of Master Manuel Cargaleiro. Cargaleiro was a multifaceted artist renowned for his painting and ceramist work. He mastered colour and geometry remarkably, giving contemporary Portuguese art its unmistakable character. Throughout his career, his creations expressed his poetic vision of the world, building a legacy recognized by several generations of Portuguese people. His work, represented in national collections such as the State Contemporary Art Collection, as well as in international ones, was highly honoured. His accolades include Commander of the Order of Santiago da Espada de Portugal (1983), Officer of the Order of Arts and Letters from the French government (1984), Grand Cross of the Order of Merit (1989), Grand Cross of the Order of Infante D. Henrique (2017), Medal of Cultural Merit (2019), Grand Vermeil Medal (2019), and the Grand Cross of the Order of Camões (2023). Cargaleiro maintained an intense artistic activity throughout his life, creating an essential legacy for 20th-century Portuguese art. His unique style bridged various references and generations. Despite being a global figure, he remained deeply connected to his roots, choosing Castelo Branco […]

A miniaturised model of human digestion to advance therapies and nutritional products

INL researchers have made a significant breakthrough in the development of reliable in-vitro digestion models. This ‘digestion-chip’ promises to revolutionise the way new oral formulations are tested, offering a more accurate, efficient, and cost-effective alternative to current models. Traditional in-vitro digestion models often fail to replicate the complex dynamics of the human gastrointestinal tract. They either lack critical digestive processes or require large volumes of samples and reagents, which can be challenging when dealing with nanomaterials. The INL’s innovative ‘digestion-chip’ addresses these limitations with its miniaturised design and advanced features. The coordinator of the study Catarina Gonçalves explains, “the Food Processing and Nutrition research group proposes a miniaturised digestion system based on incubation chambers integrated into a polymethylmethacrylate device. This solution incorporates key dynamic features of human digestion while maintaining low complexity and using small volumes of samples and reagents”. The digestion-chip features gradual acidification (the stepwise addition of enzymes and simulated fluids during the gastric phase) and controlled gastric emptying. These capabilities are essential for replicating the intricate environment of the human stomach and intestines. The research team’s experimental results indicate that “the ‘digestion-chip’ successfully replicates the established static digestion INFOGEST protocol”. Moreover, “the semi-dynamic digestion kinetics observed with […]

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