INL_GroupPhoto-Freitas_2w

NANODEVICES

NANODEVICES RESEARCH GROUP

The nanodevices group develops integrated sensor solutions for the biomedical, food and environment areas, as well as industrial sensing applications. In the biomedical sensor area, magnetoresistive based protein or DNA chips, and magnetoresistive cytometers (technologies previously developed at INESC MN-Lisbon), are now being tested in different clinical applications. The bioanalyte is labelled with a magnetic nanoparticle or bead, through an intervenient antibody, aptamer, complementary DNA strand, and after recognition, the signal is read in the magnetoresistive sensor array. Label-free technologies are also being developed, using direct molecular fingerprinting of compounds and molecules using microfluidics, an optical detection, starting with discrete assembly of pre-existent modules (microfluidic reactor, light source, optical spectrometer) to the full integration of components at the wafer level in collaboration with partners. The group (together with the spintronics group) is actively involved on the prototyping of tunnel magnetoresistive based sensors for industrial applications.

INL_GroupPhoto-Freitas_w

Nanodevices research team (picture from March 2019)

ON GOING RESEARCH PROJECTS

Project INVENNTA II (in collaboration with the neuroscience group of J Castillo, at IDIS-H Universitario de Santiago de Compostela)

Team: INL ( Elizabete Fernandes, P.P.Freitas)

           IDIS, T Sobrino, J Castillo

          Other collaborators:  S Cardoso, and T.Dias at INESC MN, under subcontract, supplying MR chip technology

project-1-300x130Conference presentation: Fernandes E., Martins V., Dias T., Germano J., Sobrino T., Cardoso S., Castillo J., Rivas J., Freitas PP. Simultaneous interrogation of multiple targets using a magnetoresistive (MR) biochip platform. Biosensors 2016, Gothenburg, Sweden 25-27 May 2016

Project INVENNTA II (in collaboration with the oncology group of R. Lopez, at IDIS-H Universitario de Santiago de Compostela)

Team: INL ( Alexandre Chicharo, P.P.Freitas, L Dieguez, B.Espina, M.Martins, J.Piteira)

            IDIS, R Lopez

            Other collaborators: S Cardoso at INESC MN, supplying MR cytometer chips

Project-2-Picture2-300x170

MR cytometer PCB, with integrated microfluidics and sensorsProject-2-Picture1-300x273

Cell labelled with magnetic beads

Conference presentation: A. Chícharo, M. Martins, B. Espiña, S. Cardoso and P. Freitas, High-throughput magnetic flow cytometer for tumour cell quantification, 13th Joint MMM-Intermag Conference, January 11-15, 2016, San Diego, California, US.

Exploiting spin transfer based nano-oscillators and spin Hall devices. Inl hosts one PhD student ( Mohammad Tarequzzaman) and has hosted one post doctoral fellow ( Bertrand Lacoste) with joint co-advising from Ricardo Ferreira (Spintronics), and P.Freitas. (more details in the spintronics group site).

This project is based on a COFUND fellowship holder ( Hongyan Bi) and addresses the specific, accurate, and fast quantification through optical means of compounds within a complex matrix background.

Schematic illustration of the microfluidic sensor integrated with after-channel UV/vis spectrophotometric detection for food ingredient analysis. (b) Collected absorbance change at 266 nm of solutions containing only caffeine, and mixture of AA and caffeine before (A0) and after (A) passing through the enzyme-loaded microfluidic sensor at 5 μL/min. Arrows indicate the time when it is started to sample the solution through the microfluidic channel.

Schematic illustration of the microfluidic sensor integrated with after-channel UV/vis spectrophotometric detection for food ingredient analysis. (b) Collected absorbance change at 266 nm of solutions containing only caffeine, and mixture of AA and caffeine before (A0) and after (A) passing through the enzyme-loaded microfluidic sensor at 5 μL/min. Arrows indicate the time when it is started to sample the solution through the microfluidic channel.

Publication: H. Bi, A. C. Fernandes, S. Cardoso and P. Freitas, Interference-Blind Microfluidic Sensor for Ascorbic Acid Determination by UV/vis Spectroscopy. Sensors and Actuators B: Chemical, 2016, 224, 668-675.

Starting project in collaboration with the Systems Engineering group, and external partners, to develop a fully integrated microspectrometer using CMOS based or a-Si:H based photodiodes, thin film multilayer band pass filters, and LEDS, into a compact format suitable for integration with control and communication hardware for a portable solution.

This project is being developed within the PhD thesis of M.Costa ( NanoFab). The goal is to incorporate magnetoresistive sensors with typical features of 100nm on the tip of AFM cantilevers, providing direct field mapping through an AFM probe.

Publication: “Integration of magnetoresistive sensors with atomic force microscopy cantilevers for scanning magnetoresistance microscopy applications”, M. Costa, J. Gaspar, R. Ferreira, E. Paz, H. Fonseca, M. Martins, S. Cardoso, and P. P. Freitas, IEEE Trans. Magnetics, vol. 51, no. 11, pp. 6503104, Nov. 2015

PUBLICATIONS

  • 2016

    Bi, H; Fernandes, A C; Cardoso, S; Freitas, P P

    Interference-blind microfluidic sensor for ascorbic acid determination by UV/vis spectroscopy Journal Article

    Sensors and Actuactos B, Chemical, 224 , pp. 668, 2016.

    BibTeX

    Huisman, T J; Mikhaylovskiy, R V; Costa, J D; Freimuth, F; Paz, E; Ventura, J; Freitas, P P; Blügel, S; Mokrousov, Y; Rasing, Th.; Kimel, T

    Femtosecond control of electric currents in metallic ferromagnetic heterostructures Journal Article

    Nature Nanotechnology, 11 , pp. 455, 2016.

    Links | BibTeX

    Vieira, N C S; Borme, J; G. Machado, ; F. Cerqueira, ; Freitas, P P; Zucolotto, V; R. Peres, N M; Alpuim, P

    Graphene field-effect transistor array with integrated electrolytic gates scaled to 200 mm Journal Article

    J. Phys. Cond. Matter, 28 , 2016.

    Links | BibTeX

    Paz, E; Ferreira, R; Freitas, P P

    Linearization of Magnetic Sensors With a Weakly Pinned Free-Layer MTJ Stack Using a Three-Step Annealing Process Journal Article

    IEEE Transactions on Magnetics, 52 (7), 2016.

    Links | BibTeX

    Freitas, P P; Ferreira, R; Cardoso, S

    Spintronic Sensors Journal Article

    Proceedings of the IEEE, 104 (10), pp. 1894-1918, 2016.

    Links | BibTeX

  • 2015

    Silvérioa, V; Cardosob, S; Gaspard, J; Freitas, P P; Moreiraa, A L N

    Design, fabrication and test of an integrated multi-microchannel heat sink for electronics cooling Journal Article

    Sensors and Actuactors A, Physical, 235 (14), pp. 235, 2015.

    BibTeX

    Costa, J D; Serrano-Guisan, S; Borme, J; Deepak, F L; Tarequzzaman, M; Paz, E; Ventura, J; Ferreira, R; Freitas, P P

    Impact of MgO Thickness on the Performance of Spin-Transfer Torque Nano-Oscillators Journal Article

    IEEE Transactions on Magnetics , 51 (11), 2015.

    Links | BibTeX

    Costa, M; Gaspar, J; Ferreira, R; Paz, E; Fonseca, H; Martins, M; Cardoso, S; Freitas, P P

    Integration of magnetoresistive sensors with atomic force microscopy cantilevers for scanning magnetoresistance microscopy applications Journal Article

    IEEE Transactions on Magnetics, 51 , 2015.

    BibTeX

    Silva, A V; Leitao, D C; Valadeiro, J; Amaral, J; Freitas, P P; Cardoso, S

    Linearization strategies for high sensitivity magnetoresistive sensors Journal Article

    Eur. Phys. J. Appl. Phys., 72 , 2015.

    BibTeX

    Couto, D; Sousa, R; Andrade, L; Leander, M; Lopez-Quintela, M A; Rivas, J; Freitas, P P; Lima, M; Porto, G; Porto, B; Carvalho, F; Fernandes, E

    Polyacrylic acid coated and non-coated iron-oxide nanoparticles are not genotoxic to human T-lymphocites Journal Article

    Toxicology Letters, 234 (67), 2015.

    BibTeX

GROUP LEADER

Paulo Freitas - 1

THE TEAM

Staff Researchers:

Elisabete Fernandes
Staff researcher

Hugo Oliveira
Staff researcher

Bruno Silva
Staff Researcher

Research Fellows:

Carla Carvalho
Research Fellow

Denis Santos
Research Fellow

Ana Frangolho
Research Fellow

Diana Pinho
Research Fellow

Briliant Prabowo
Research Fellow

Ricardo Gaspar
Research Fellow

Iria Garcia
Research Fellow

PhD Students:

Helena Domingues
PhD Student

Francisca Fonseca
PhD Student

MSc Students:

Miguel Amaral
Master student (U Porto)

NANODEVICES RESEARCH GROUP

The nanodevices group develops integrated sensor solutions for the biomedical, food and environment areas, as well as industrial sensing applications. In the biomedical sensor area, magnetoresistive based protein or DNA chips, and magnetoresistive cytometers (technologies previously developed at INESC MN-Lisbon), are now being tested in different clinical applications. The bioanalyte is labelled with a magnetic nanoparticle or bead, through an intervenient antibody, aptamer, complementary DNA strand, and after recognition, the signal is read in the magnetoresistive sensor array. Label-free technologies are also being developed, using direct molecular fingerprinting of compounds and molecules using microfluidics, an optical detection, starting with discrete assembly of pre-existent modules (microfluidic reactor, light source, optical spectrometer) to the full integration of components at the wafer level in collaboration with partners. The group (together with the spintronics group) is actively involved on the prototyping of tunnel magnetoresistive based sensors for industrial applications.

INL_GroupPhoto-Freitas_w

Nanodevices research team (picture from March 2019)

ON GOING RESEARCH PROJECTS

Project INVENNTA II (in collaboration with the neuroscience group of J Castillo, at IDIS-H Universitario de Santiago de Compostela)

Team: INL ( Elizabete Fernandes, P.P.Freitas)

           IDIS, T Sobrino, J Castillo

          Other collaborators:  S Cardoso, and T.Dias at INESC MN, under subcontract, supplying MR chip technology

project-1-300x130Conference presentation: Fernandes E., Martins V., Dias T., Germano J., Sobrino T., Cardoso S., Castillo J., Rivas J., Freitas PP. Simultaneous interrogation of multiple targets using a magnetoresistive (MR) biochip platform. Biosensors 2016, Gothenburg, Sweden 25-27 May 2016

Project INVENNTA II (in collaboration with the oncology group of R. Lopez, at IDIS-H Universitario de Santiago de Compostela)

Team: INL ( Alexandre Chicharo, P.P.Freitas, L Dieguez, B.Espina, M.Martins, J.Piteira)

            IDIS, R Lopez

            Other collaborators: S Cardoso at INESC MN, supplying MR cytometer chips

Project-2-Picture2-300x170

MR cytometer PCB, with integrated microfluidics and sensorsProject-2-Picture1-300x273

Cell labelled with magnetic beads

Conference presentation: A. Chícharo, M. Martins, B. Espiña, S. Cardoso and P. Freitas, High-throughput magnetic flow cytometer for tumour cell quantification, 13th Joint MMM-Intermag Conference, January 11-15, 2016, San Diego, California, US.

Exploiting spin transfer based nano-oscillators and spin Hall devices. Inl hosts one PhD student ( Mohammad Tarequzzaman) and has hosted one post doctoral fellow ( Bertrand Lacoste) with joint co-advising from Ricardo Ferreira (Spintronics), and P.Freitas. (more details in the spintronics group site).

This project is based on a COFUND fellowship holder ( Hongyan Bi) and addresses the specific, accurate, and fast quantification through optical means of compounds within a complex matrix background.

Schematic illustration of the microfluidic sensor integrated with after-channel UV/vis spectrophotometric detection for food ingredient analysis. (b) Collected absorbance change at 266 nm of solutions containing only caffeine, and mixture of AA and caffeine before (A0) and after (A) passing through the enzyme-loaded microfluidic sensor at 5 μL/min. Arrows indicate the time when it is started to sample the solution through the microfluidic channel.

Schematic illustration of the microfluidic sensor integrated with after-channel UV/vis spectrophotometric detection for food ingredient analysis. (b) Collected absorbance change at 266 nm of solutions containing only caffeine, and mixture of AA and caffeine before (A0) and after (A) passing through the enzyme-loaded microfluidic sensor at 5 μL/min. Arrows indicate the time when it is started to sample the solution through the microfluidic channel.

Publication: H. Bi, A. C. Fernandes, S. Cardoso and P. Freitas, Interference-Blind Microfluidic Sensor for Ascorbic Acid Determination by UV/vis Spectroscopy. Sensors and Actuators B: Chemical, 2016, 224, 668-675.

Starting project in collaboration with the Systems Engineering group, and external partners, to develop a fully integrated microspectrometer using CMOS based or a-Si:H based photodiodes, thin film multilayer band pass filters, and LEDS, into a compact format suitable for integration with control and communication hardware for a portable solution.

This project is being developed within the PhD thesis of M.Costa ( NanoFab). The goal is to incorporate magnetoresistive sensors with typical features of 100nm on the tip of AFM cantilevers, providing direct field mapping through an AFM probe.

Publication: “Integration of magnetoresistive sensors with atomic force microscopy cantilevers for scanning magnetoresistance microscopy applications”, M. Costa, J. Gaspar, R. Ferreira, E. Paz, H. Fonseca, M. Martins, S. Cardoso, and P. P. Freitas, IEEE Trans. Magnetics, vol. 51, no. 11, pp. 6503104, Nov. 2015

PUBLICATIONS

  • 2016

    Bi, H; Fernandes, A C; Cardoso, S; Freitas, P P

    Interference-blind microfluidic sensor for ascorbic acid determination by UV/vis spectroscopy Journal Article

    Sensors and Actuactos B, Chemical, 224 , pp. 668, 2016.

    BibTeX

    Huisman, T J; Mikhaylovskiy, R V; Costa, J D; Freimuth, F; Paz, E; Ventura, J; Freitas, P P; Blügel, S; Mokrousov, Y; Rasing, Th.; Kimel, T

    Femtosecond control of electric currents in metallic ferromagnetic heterostructures Journal Article

    Nature Nanotechnology, 11 , pp. 455, 2016.

    Links | BibTeX

    Vieira, N C S; Borme, J; G. Machado, ; F. Cerqueira, ; Freitas, P P; Zucolotto, V; R. Peres, N M; Alpuim, P

    Graphene field-effect transistor array with integrated electrolytic gates scaled to 200 mm Journal Article

    J. Phys. Cond. Matter, 28 , 2016.

    Links | BibTeX

    Paz, E; Ferreira, R; Freitas, P P

    Linearization of Magnetic Sensors With a Weakly Pinned Free-Layer MTJ Stack Using a Three-Step Annealing Process Journal Article

    IEEE Transactions on Magnetics, 52 (7), 2016.

    Links | BibTeX

    Freitas, P P; Ferreira, R; Cardoso, S

    Spintronic Sensors Journal Article

    Proceedings of the IEEE, 104 (10), pp. 1894-1918, 2016.

    Links | BibTeX

  • 2015

    Silvérioa, V; Cardosob, S; Gaspard, J; Freitas, P P; Moreiraa, A L N

    Design, fabrication and test of an integrated multi-microchannel heat sink for electronics cooling Journal Article

    Sensors and Actuactors A, Physical, 235 (14), pp. 235, 2015.

    BibTeX

    Costa, J D; Serrano-Guisan, S; Borme, J; Deepak, F L; Tarequzzaman, M; Paz, E; Ventura, J; Ferreira, R; Freitas, P P

    Impact of MgO Thickness on the Performance of Spin-Transfer Torque Nano-Oscillators Journal Article

    IEEE Transactions on Magnetics , 51 (11), 2015.

    Links | BibTeX

    Costa, M; Gaspar, J; Ferreira, R; Paz, E; Fonseca, H; Martins, M; Cardoso, S; Freitas, P P

    Integration of magnetoresistive sensors with atomic force microscopy cantilevers for scanning magnetoresistance microscopy applications Journal Article

    IEEE Transactions on Magnetics, 51 , 2015.

    BibTeX

    Silva, A V; Leitao, D C; Valadeiro, J; Amaral, J; Freitas, P P; Cardoso, S

    Linearization strategies for high sensitivity magnetoresistive sensors Journal Article

    Eur. Phys. J. Appl. Phys., 72 , 2015.

    BibTeX

    Couto, D; Sousa, R; Andrade, L; Leander, M; Lopez-Quintela, M A; Rivas, J; Freitas, P P; Lima, M; Porto, G; Porto, B; Carvalho, F; Fernandes, E

    Polyacrylic acid coated and non-coated iron-oxide nanoparticles are not genotoxic to human T-lymphocites Journal Article

    Toxicology Letters, 234 (67), 2015.

    BibTeX

GROUP LEADER

Paulo Freitas - 1

THE TEAM

Staff Researchers:

Elisabete Fernandes
Staff researcher

Hugo Oliveira
Staff researcher

Bruno Silva
Staff Researcher

Research Fellows:

Denis Santos
Research Fellow

Carla Carvalho
Research Fellow

Ana Frangolho
Research Fellow

Diana Pinho
Research Fellow

Briliant Prabowo
Research Fellow

Ricardo Gaspar
Research Fellow

Iria Garcia
Research Fellow

PhD Students:

Helena Domingues
PhD Student

Francisca Fonseca
PhD Student

MSc Students:

Miguel Amaral
Master student (U Porto)