Nanodevices
The nanodevices group develops integrated sensor solutions for the biomedical, food and environment areas, as well as industrial sensing applications. In the biomedical sensor area, magnetoresistive based protein or DNA chips, and magnetoresistive cytometers (technologies previously developed at INESC MN-Lisbon), are now being tested in different clinical applications. The bioanalyte is labelled with a magnetic nanoparticle or bead, through an intervenient antibody, aptamer, complementary DNA strand, and after recognition, the signal is read in the magnetoresistive sensor array. Label-free technologies are also being developed, using direct molecular fingerprinting of compounds and molecules using microfluidics, an optical detection, starting with discrete assembly of pre-existent modules (microfluidic reactor, light source, optical spectrometer) to the full integration of components at the wafer level in collaboration with partners. The group (together with the spintronics group) is actively involved on the prototyping of tunnel magnetoresistive based sensors for industrial applications.
Research lines:
- Magnetic tunnel junction sensor pilot line
- Biosensors (magnetoresistive and others)
- Novel sensing platforms
Projects
Publications
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A pump-free microfluidic device for fast magnetic labeling of ischemic stroke biomarkers
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 20221.1-Millimeter Tall Vertically Aligned-Carbon Nanotubes Grown by Cold Wall CVD Using a Novel Multiple-Purge Method
ADVANCED MATERIALS INTERFACES, 2022Evolution in Automatized Detection of Cells: Advances in Magnetic Microcytometers for Cancer Cells
, 2022MEMS resonators with electrostatic actuation and piezoresistive readout for sensing applications
MICRO AND NANO ENGINEERING, 2022Versatile and Low-Cost Fabrication of Modular Lock-and-Key Microfluidics for Integrated Connector Mixer Using a Stereolithography 3D Printing
MICROMACHINES, 2022A Novel Approach for Monitoring the Volatile Metabolome in Biological Samples from Ruminants through Miniaturized Liquid-Liquid Extraction and Multiclass Gas Chromatography Analysis
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2022A Phage Receptor-Binding Protein as a Promising Tool for the Detection of Escherichia coli in Human Specimens
FRONTIERS IN MICROBIOLOGY, 2022Burden of bacterial bloodstream infections and recent advances for diagnosis
PATHOGENS AND DISEASE, 2022Monolithic Integration of Multi-Spectral Optical Interference Filter Array on Thin Film Amorphous Silicon Photodiodes
IEEE SENSORS JOURNAL, 2022Monolithically integrated optical interference and absorption filters on thin film amorphous silicon photosensors for biological detection
SENSORS AND ACTUATORS B-CHEMICAL, 2022Optimizing PMMA solutions to suppress contamination in the transfer of CVD graphene for batch production
BEILSTEIN JOURNAL OF NANOTECHNOLOGY, 2022Suggestion for a new bacteriophage genus for the Klebsiella pneumoniae phage vB_KpnS-Carvaje
CURRENT GENETICS, 2022Potential of bacteriophage proteins as recognition molecules for pathogen detection.
, 2022 -
Cationic Lipid-Based Formulations for Encapsulation and Delivery of Anti-EFG1 2’OMethylRNA Oligomer
, 2021The Challenges of Developing Biosensors for Clinical Assessment: A Review
CHEMOSENSORS, 2021Establishment of Colorectal Cancer Organoids in Microfluidic-Based System
MICROMACHINES, 2021Combining magnetic and optical approaches for the multiplex detection of bacteria in blood
, 2021Gold nanoparticle-assisted plasmonic enhancement for DNA detection on a graphene-based portable surface plasmon resonance sensor
NANOTECHNOLOGY, 2021Gold Nanoframe Array Electrode for Straightforward Detection of Hydrogen Peroxide
CHEMOSENSORS, 2021Influence of the media ionic strength on the formation and in vitro biological performance of polycation-DNA complexes
JOURNAL OF MOLECULAR LIQUIDS, 2021Optical specifications for a proximal sensing approach to monitor the vine water status in a distributed and autonomous fashion
BIOSYSTEMS ENGINEERING, 2021 -
Development of Organoid-on-a-chip Platform for Preclinical Drug Screening
, 2020Fluorescencecross-correlationspectroscopy as a valuable tool to characterize cationicliposome-DNAnanoparticle assembly
JOURNAL OF BIOPHOTONICS, 2020Lipid-Nucleic Acid Complexes: Physicochemical Aspects and Prospects for Cancer Treatment
MOLECULES, 2020Point-of-care quantification of serum cellular fibronectin levels for stratification of ischemic stroke patients'
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2020Rhamnolipids-based nanostructured lipid carriers: Effect of lipid phase on physicochemical properties and stability
FOOD CHEMISTRY, 2020ZnO-Nanorod processed PC-SET as the light-harvesting model for plasmontronic fluorescence Sensor
SENSORS AND ACTUATORS B-CHEMICAL, 2020In Vitro Evaluation of Lipopolyplexes for Gene Transfection: Comparing 2D, 3D and Microdroplet-Enabled Cell Culture
MOLECULES, 2020Clean-Room Lithographical Processes for the Fabrication of Graphene Biosensors
MATERIALS, 2020Rapidly dissolving microneedles for the delivery of cubosome-like liquid crystalline nanoparticles with sustained release of rapamycin
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2020Facile Bacterial Cellulose Nanofibrillation for the Development of a Plasmonic Paper Sensor
ACS BIOMATERIALS SCIENCE & ENGINEERING, 2020 -
Specific detection of viable Salmonella Enteritidis by phage amplification combined with qPCR (PAA-qPCR) in spiked chicken meat samples
FOOD CONTROL, 2019Amplification-free SERS analysis of DNA mutation in cancer cells with single-base sensitivity
NANOSCALE, 2019Flexible and expeditious assay for quantitative monitoring of alpha-amylase and amyloglucosidase activities
METHODSX, 2019Functionalization of single-layer graphene for immunoassays
APPLIED SURFACE SCIENCE, 2019Unravelling the phytonutrients and antioxidant properties of European Vicia faba L. seeds
FOOD RESEARCH INTERNATIONAL, 2019