Rui Campos Advances Biosensor Research at INL

Rui Campos, working in the Diéguez Research Group at INL – International Iberian Nanotechnology Laboratory since October 2024, is developing a biosensor for continuous detection of inflammation biomarkers as part of the WINGS project funded by the La Caixa Foundation – Health Research Programme. His research focuses on bioelectrochemical assays for detecting nucleic acids, proteins, and small molecules.

Dr. Campos earned his Ph.D. in Chemistry from Durham University (UK) in 2013. He has conducted postdoctoral research at Aarhus University (Denmark), INL (Portugal), and the University of Antwerp (Belgium), where he developed a biosensor for prostate cancer microRNAs under the Marie Skłodowska-Curie Actions fellowship.

In this interview, Dr. Campos shares his journey in biosensor research, contributions to the WINGS project, and advice for young researchers in nanotechnology and biomedical applications.

What drew you to biosensor research, and how has your journey across different institutions shaped your expertise? My interest in biosensor research was sparked by the potential to create innovative solutions for real-world problems, particularly in healthcare. The ability to develop devices that can detect and monitor biological markers with high sensitivity and specificity is incredibly exciting.
My journey across different institutions has been instrumental in shaping my expertise. At Durham, UK, during my PhD, I learned about electrochemical sensors and the possibilities they offer. In Aarhus, Denmark, during my postdoc, I focused on oligonucleotide-based biosensors. As a Marie-Curie fellow in Antwerp, Belgium, I explored a new type of photoelectrochemical biosensors for liquid biopsy. At INL, I delved into graphene sensors and applied all the knowledge previously acquired to develop biosensors for the food industry, antibiotic resistance detection, and liquid biopsy. These experiences have broadened my perspective and deepened my understanding of the interdisciplinary nature of biosensor research.

Your work in the WINGS project focuses on detecting inflammation biomarkers. How do you see this technology impacting healthcare? The technology developed in the WINGS projec has the potential to revolutionise healthcare by enabling early and accurate detection of inflammation biomarkers and, in the specific case of this project, those related to spinal cord injury. This can lead to timely diagnosis, more accurate prognoses, and personalized therapies, ultimately improving patient outcomes and reducing healthcare costs.
Additionally, this technology can be used to monitor chronic inflammatory conditions, allowing for personalized treatment plans and better disease management. The ability to detect inflammation biomarkers quickly and non-invasively also opens possibilities for point-of-care testing, making healthcare more accessible and efficient.

You’ve worked on bioelectrochemical assays for nucleic acids, proteins, and small molecules. What do you find most exciting about this field and its future? What excites me most about the field of bioelectrochemical assays is its versatility and potential for innovation. The ability to detect a wide range of biomolecules with high precision opens numerous applications in diagnostics, environmental monitoring, and even food safety. The future of this field is promising, with advancements in nanotechnology and materials science driving the development of more sensitive, selective, and cost-effective assays. I am particularly excited about the integration of these assays with digital technologies, which could lead to smart diagnostic devices and real-time health monitoring systems.

What advice would you give to young researchers looking to work at the intersection of nanotechnology and biomedical applications? My advice to young researchers is to embrace interdisciplinary collaboration and stay curious. The intersection of nanotechnology and biomedical applications is a rapidly evolving field that requires knowledge from various disciplines. Building a strong foundation in both areas and seeking opportunities to work with experts from different fields can significantly enhance your research. Additionally, stay updated with the latest advancements and be open to exploring new ideas and approaches.

Persistence and creativity are key, as the path to innovation often involves overcoming numerous challenges.

Interview and Photography by Gina Palha, Communication, Conferences & Marketing Officer