Catarina Gonçalves is currently a staff researcher in the Food Processing and Nutrition Group. She works on the risk assessment of engineered nanomaterials for oral administration, focusing on how nanomaterials behave (safety and efficacy) under human digestive conditions. A microfluidic-based device is being developed to simulate the complete gastrointestinal tract, including a cell-based module (Caco-2 and HT29-MTX cell lines derived from the human intestinal epithelium) to predict biological responses. Catarina also performs in vitro cytotoxicity tests, assessing cell viability, membrane integrity, oxidative stress and inflammatory responses.
Catarina holds a Diploma (2004) in Chemical Engineering from ISEP, Porto and a PhD degree (2010) in Biomedical Engineering from the University of Minho, Braga, Portugal. As a postdoctoral researcher (2010-2016) at the Centre of Biological Engineering in Braga, she worked on the chemical modification of natural polymers for nanogels preparation (through self-assembly) and their physic-chemical characterization, nanoencapsulation and release studies (small molecules and proteins), cytotoxicity evaluation and in vivo biodistribution studies (mice and rat models). Catarina also worked with radiolabeled nanogels stabilizing γ-Fe2O3 for use as a dual-modality probe, combining SPECT and MRI.
Recent Advances in Cell-Based In Vitro Models to Recreate Human Intestinal Inflammation
ADVANCED SCIENCE, 2023
Effect of prebiotic fermentation products from primary human gut microbiota on an in vitro intestinal model
JOURNAL OF FUNCTIONAL FOODS, 2022
Safety and fate of nanomaterials in food: The role of in vitro tests
TRENDS IN FOOD SCIENCE & TECHNOLOGY, 2021
In Vitro Intestinal Uptake And Permeability Of Fluorescently-Labelled Hyaluronic Acid Nanogels
INTERNATIONAL JOURNAL OF NANOMEDICINE, 2019