Bruno Silva

Staff Researcher
Nanodevices

Bruno Silva is currently a staff researcher in the Nanodevices group at INL. Dr Silva’s main interest is to use colloidal science and nanotechnology to provide better gene delivery solutions for healthcare.
To achieve this goal the team relies on (i) microfluidic device fabrication to manipulate and control lipid-DNA nanoparticle formation, and on (ii) advanced characterization methods such as synchrotron small-angle X-ray scattering (SAXS), small-angle neutron scattering (SANS) and fluorescence cross-correlation spectroscopy (FCCS) to provide important insights about how mRNA and DNA interact with liposomes to form structurally-diverse nanoparticles. This knowledge is crucial to improve formulation efficacy in therapeutic applications.

Bruno Silva holds a PhD (2009) in Chemistry from the University of Porto, Portugal, where he worked in the topics of Physical Chemistry, Soft Matter and Colloidal Science. He focused on the phase behaviour and nanostructure of self-assembled surfactant systems, using small-angle neutron scattering (SANS) as the main characterization tool. As a Marie Curie postdoctoral fellow at the University of California Santa Barbara, USA, and Lund University, Sweden, he worked on the structural control of cationic liposome-DNA nanoparticles (also known as CL-DNAs or lipoplexes) and on the development of microfluidic devices with in-situ small-angle x-ray scattering (SAXS) for studies of soft matter underflow and out-of-equilibrium conditions.

Selected Publications