
Vânia Vilas-Boas
Research Fellow
Nanosafety
Vânia is a Research Fellow in the Nanosafety group, under the guidance of Dr Alfaro-Moreno. Her work is dedicated to the development of multiplexed in vitro methodologies for nanotoxicological assessment.
Vânia is a pharmacist (PharmD, 2005) holding a Master (2009) and a PhD (2017) in Toxicology from the Faculty of Pharmacy, University of Porto. Prior to joining INL, she was awarded a Marie-Curie Individual Fellowship to develop her postdoctoral studies on the mechanisms of chemical-induced cholestasis in the group of Prof. Vinken, at the Vrije Universiteit Brussel. During this period, she did a long research stay in Prof. Ingelman-Sundberg’s lab, at the Karolinska Institutet, where she learnt 3D cultures of primary human hepatocytes. Previously, she has explored different topics within the bigger field of Toxicology, namely the analysis of nanomaterials in wastewater samples, guided by Dr. B. Espiña, the use of magnetic hyperthermia for cancer treatment, mentored by Prof. Félix Carvalho, and the screening of new antidotes for intoxications with paraquat, in Prof. F. Remião’s group. Her main research interest is in vitro modelling for (nano)toxicological and drug discovery purposes.
Selected Publications
- V. Vilas-Boas and M. Vinken (2021)
Hepatotoxicity induced by nanomaterials: mechanisms and in vitro models
Archives of Toxicology 95(1): 27-52
- E. Gijbels, V. Vilas‐Boas, P. Annaert, T. Vanhaecke, L. Devisscher, M. Vinken (2020)
Robustness testing and optimization of an adverse outcome pathway on cholestatic liver injury
Archives of Toxicology 93(5): 1169-1186
- V. Vilas-Boas, B. Espiña, Y.V. Kolen’ko, M. Bañobre-Lopez, M. Brito, V.C. Martins, J.A. Duarte, D. Petrovykh, P. Freitas, F. Carvalho (2019)
Effectiveness and safety of a nontargeted boost for a CXCR4-targeted magnetic hyperthermia treatment of cancer cells
ACS Omega 13, 411931-1940
- R. Silva, V. Vilas-Boas, H. Carmo, R. Dinis-Oliveira, F. Carvalho, M. L. Bastos and F. Remião (2014)
Modulation of P-glycoprotein efflux pump: induction and activation as a therapeutic strategy
Pharmacology & Therapeutics 149, 1-123
- V. Vilas-Boas, R. Silva, C. Nunes, S. Reis, L. Ferreira, C. Vieira, F. Carvalho, M.L. Bastos, F. Remião (2013)
Mechanisms of P-gp inhibition and effects on membrane fluidity of a new rifampicin derivative, 1,8-dibenzoyl-rifampicin
Toxicology Letters 220(3): 259-66